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E2F1 抗体

This anti-E2F1 antibody is a 兔 单克隆 antibody detecting E2F1 in WB 和 IP. Suitable for 人.
产品编号 ABIN7266873
发货至: 中国

Quick Overview for E2F1 抗体 (ABIN7266873)

抗原

See all E2F1 抗体
E2F1 (E2F Transcription Factor 1 (E2F1))

适用

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宿主

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克隆类型

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单克隆

标记

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This E2F1 antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunoprecipitation (IP)
  • 原理

    E2F1 Rabbit mAb

    交叉反应

    人, 小鼠, 大鼠

    产品特性

    Monoclonal Antibodies

    纯化方法

    Affinity purification

    免疫原

    A synthesized peptide derived from human E2F1.

    亚型

    IgG
  • 应用备注

    WB,1:500 - 1:2000,IP,1:50 - 1:200

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    PBS with 0.02 % sodium azide,0.05 % BSA,50 % glycerol, pH 7.3.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    Store at -20°C. Avoid freeze / thaw cycles.
  • 抗原

    E2F1 (E2F Transcription Factor 1 (E2F1))

    别名

    E2F1

    背景

    The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis. [provided by RefSeq, Jul 2008],E2F-1,RBAP1,RBBP3,RBP3,E2F1,Apoptosis,Cancer,Cell Biology & Developmental Biology,Cell Cycle,Epigenetics & Nuclear Signaling,ErbB-HER Signaling Pathway,G1/S Checkpoint,Signal Transduction,Transcription Factors,Tumor suppressors,E2F1

    分子量

    46kDa

    基因ID

    1869

    UniProt

    Q01094

    途径

    p53 Pathway, Cell Division Cycle, Mitotic G1-G1/S Phases, DNA Replication, M Phase, Autophagy
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