ROR2 抗体 (AA 2535-2835)
Quick Overview for ROR2 抗体 (AA 2535-2835) (ABIN7232906)
抗原
See all ROR2 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 2535-2835
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原理
- Anti-ROR2 Mouse Monoclonal Antibody
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特异性
- Mouse and human ROR2. Does not cross-react with ROR1.
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交叉反应
- 人, 小鼠
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纯化方法
- Purified by Protein G affinity chromatography
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免疫原
- Bases 2535-2835 of mouse ROR2 fused in-frame to MBP and expressed in E. coli.
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亚型
- IgG1
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anti-Receptor Tyrosine Kinase-Like Orphan Receptor 2 (ROR2) (AA 683-934) antibody
ROR2 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Receptor Tyrosine Kinase-Like Orphan Receptor 2 (ROR2) (AA 59-155) antibodyROR2 适用: 人 ELISA, FACS 宿主: 小鼠 Monoclonal 6F2D10 unconjugated
anti-Receptor Tyrosine Kinase-Like Orphan Receptor 2 (ROR2) (AA 19-50), (N-Term) antibodyROR2 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB01507-01508 unconjugated
anti-Receptor Tyrosine Kinase-Like Orphan Receptor 2 (ROR2) (AA 19-50) antibodyROR2 适用: 人 WB, IHC, ELISA, FACS 宿主: 兔 Polyclonal unconjugated
anti-Receptor Tyrosine Kinase-Like Orphan Receptor 2 (ROR2) (AA 752-926) antibodyROR2 适用: 人 IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Receptor Tyrosine Kinase-Like Orphan Receptor 2 (ROR2) (AA 915-943), (C-Term) antibodyROR2 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB01510 unconjugated
anti-Receptor Tyrosine Kinase-Like Orphan Receptor 2 (ROR2) (Internal Region) antibodyROR2 适用: 人, 小鼠 WB, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Receptor Tyrosine Kinase-Like Orphan Receptor 2 (ROR2) (AA 34-143) antibodyROR2 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 4E1 unconjugated
anti-Receptor Tyrosine Kinase-Like Orphan Receptor 2 (ROR2) antibodyROR2 适用: 人 IHC, StM 宿主: 小鼠 Monoclonal ROR2-1911 unconjugated
anti-Receptor Tyrosine Kinase-Like Orphan Receptor 2 (ROR2) (AA 100-200) antibodyROR2 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
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Immunoblotting: use at 1-10 μg/mL. A band of ~105 kDa is detected.
Immunohistochemistry: use at 1-10 μg/mL on paraformaldehyde-fixed, paraffin-embedded sections following antigen retrieval (microwave 12 min in citrate buffer, pH 6.0).
These are recommended concentrations.
Enduser should determine optimal concentrations for their application. -
限制
- 仅限研究用
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状态
- Liquid
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溶解方式
- Dilute in PBS or medium that is identical to that used in the assay system.
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浓度
- Lot specific
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缓冲液
- PBS, pH 7.4
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储存条件
- -20 °C
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储存方法
- This antibody is stable for at least one (1) year at -20°C.
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- ROR2 (Receptor Tyrosine Kinase-Like Orphan Receptor 2 (ROR2))
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别名
- ROR2
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背景
- Tyrosine-protein kinase transmembrane receptor ROR2,Tyrosine-protein kinase receptor which may be involved in the early formation of the chondrocytes. It seems to be required for cartilage and growth plate development (By similarity). Phosphorylates YWHAB, leading to induction of osteogenesis and bone formation (PubMed:17717073). In contrast, has also been shown to have very little tyrosine kinase activity in vitro. May act as a receptor for wnt ligand WNT5A which may result in the inhibition of WNT3A-mediated signaling (PubMed:25029443). {UniProtKB:Q9Z138, PubMed:17717073, PubMed:25029443}.,Receptor tyrosine kinases (RTKs) are cell surface receptors that regulate normal cellular processes through ligand-controlled tyrosine kinase activity. ROR2 is a membrane-bound RTK that is activated by Wnt signaling during normal bone and cartilage development. Recently, ROR2 has been shown to have pro-tumorigenic effects in osteosarcoma, melanoma, and renal cell carcinoma cell lines. ROR2 levels have also been described in soft-tissue sarcomas, specifically, in vitro studies revealed that invasive abilities of leiomyosarcoma (LMS) and gastrointestinal stromal tumor (GIST) are affected by ROR2 expression, and suppression of ROR2 reduces in vivo tumor mass in a xenotransplantation model of LMS.,Cell membrane, Single-pass type I membrane protein,EC 2.7.10.1, Neurotrophic tyrosine kinase, receptor-related 2
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UniProt
- Q01974
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途径
- RTK signaling, WNT signaling
抗原
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