14-3-3 sigma/SFN 抗体 (AA 10-90)
Quick Overview for 14-3-3 sigma/SFN 抗体 (AA 10-90) (ABIN7221170)
抗原
See all 14-3-3 sigma/SFN (SFN) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 10-90
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原理
- 14-3-3 σ Polyclonal Antibody
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特异性
- 14-3-3 σ Polyclonal Antibody detects endogenous levels of 14-3-3 σ protein.
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
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免疫原
- Synthesized peptide derived from the Internal region of human 14-3-3 sigma at AA range: 10-90
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亚型
- IgG
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), ELISA (1:20000). Not yet tested in other applications.
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说明
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Primary Antibody
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
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- 14-3-3 sigma/SFN (SFN) (Stratifin (SFN))
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别名
- 14-3-3 sigma
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背景
- Rabbit Anti-14-3-3 σ Polyclonal Antibody,SFN, HME1, 14-3-3 protein sigma, Epithelial cell marker protein 1, Stratifin,SFN (Stratifin) is a Protein Coding gene. Diseases associated with SFN include pancreatic ductal adenocarcinoma and limbal stem cell deficiency. Among its related pathways are Gene Expression and Signaling by GPCR. GO annotations related to this gene include protein kinase binding and phosphoprotein binding. An important paralog of this gene is YWHAZ. dapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53. 53-regulated inhibitor of G2/M progression.,14-3-3 protein sigma
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基因ID
- 2810
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UniProt
- P31947
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途径
- p53 Pathway, Myometrial Relaxation and Contraction
抗原
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