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Dual Specificity Phosphatase 3 (DUSP3) (AA 41-140) 抗体 (HRP)

This anti- antibody is a 兔 多克隆 antibody detecting in WB, ELISA, IHC (p) 和 IHC (fro). Suitable for 小鼠.
产品编号 ABIN716330
发货至: 中国

Quick Overview for Dual Specificity Phosphatase 3 (DUSP3) (AA 41-140) 抗体 (HRP) (ABIN716330)

抗原

See all Dual Specificity Phosphatase 3 (DUSP3) 抗体
Dual Specificity Phosphatase 3 (DUSP3)

适用

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小鼠

宿主

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克隆类型

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多克隆

标记

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HRP

应用范围

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Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
  • 抗原表位

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    AA 41-140

    交叉反应

    小鼠

    预测反应

    Human,Rat,Cow,Sheep,Pig,Horse,Rabbit

    纯化方法

    Purified by Protein A.

    免疫原

    KLH conjugated synthetic peptide derived from human DUSP3

    亚型

    IgG
  • 应用备注

    WB 1:300-5000
    IHC-P 1:200-400
    IHC-F 1:100-500

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    1 μg/μL

    缓冲液

    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

    储存液

    ProClin

    注意事项

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    注意事项

    Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

    储存条件

    -20 °C

    储存方法

    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

    有效期

    12 months
  • 抗原

    Dual Specificity Phosphatase 3 (DUSP3)

    别名

    DUSP3

    背景

    Synonyms: Dual specicity phosphatase 3, Dual specicity protein phosphatase 3, Dual specicity protein phosphatase VHR, DUS3_HUMAN, DUSP3, Serine/threonine specic protein phosphatase, Vaccinia H1-related phosphatase, Vaccinia virus phosphatase VH1 related, VHR.

    Background: The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene maps in a region that contains the BRCA1 locus which confers susceptibility to breast and ovarian cancer. Although DUSP3 is expressed in both breast and ovarian tissues, mutation screening in breast cancer pedigrees and in sporadic tumors was negative, leading to the conclusion that this gene is not BRCA1.

    基因ID

    1845

    途径

    Neurotrophin Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades
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