MTA1 抗体 (AA 140-220)
Quick Overview for MTA1 抗体 (AA 140-220) (ABIN7225822)
抗原
See all MTA1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 140-220
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原理
- MTA1 Polyclonal Antibody
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特异性
- MTA1 Polyclonal Antibody detects endogenous levels of MTA1 protein.
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
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免疫原
- Synthesized peptide derived from the Internal region of human MTA1 at AA range: 140-220
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亚型
- IgG
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), IHC-P (1:100-1:300), ELISA (1:40000). Not yet tested in other applications.
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说明
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Primary Antibody
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
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- MTA1 (Metastasis Associated 1 (MTA1))
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别名
- MTA1
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背景
- Rabbit Anti-MTA1 Polyclonal Antibody,MTA1, Metastasis-associated protein MTA1,MTA1 (metastasis associated 1) encodes a protein that was identified in a screen for genes expressed in metastatic cells, specifically, mammary adenocarcinoma cell lines. Expression of MTA1 has been correlated with the metastatic potential of at least two types of carcinomas although it is also expressed in many normal tissues. The role it plays in metastasis is unclear. It was initially thought to be the 70kD component of a nucleosome remodeling deacetylase complex, NuRD, but it is more likely that this component is a different but very similar protein. These two proteins are so closely related, though, that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. The profile and activity of this gene product suggest that it is involved in regulating transcription and that this may be accomplished by chromatin remodeling. Two transcript variants encoding different isoforms have been found for MTA1.,Metastasis-associated protein MTA1
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分子量
- observerd band 80kDa
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基因ID
- 9112
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UniProt
- Q13330
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途径
- Chromatin Binding
抗原
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