IL12RB2 抗体 (AA 270-350)
Quick Overview for IL12RB2 抗体 (AA 270-350) (ABIN7228994)
抗原
See all IL12RB2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 270-350
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原理
- I12R2 Polyclonal Antibody
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特异性
- The antibody detects endogenous levels of I12R2 protein
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纯化方法
- The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen
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免疫原
- Synthesized peptide derived from part region of human I12R2 protein at AA range: 270-350
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亚型
- IgG
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), ELISA (1:5000-1:20000).
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说明
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Primary Antibody
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- PBS, pH 7.4, containing 0.02 % Sodium Azide as preservative and 50 % Glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
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- IL12RB2 (Interleukin 12 Receptor, beta 2 (IL12RB2))
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别名
- I12R2
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背景
- Rabbit Anti-I12R2 Polyclonal Antibody,Interleukin-12 receptor subunit beta-2, IL-12 receptor subunit beta-2, IL-12R subunit beta-2, IL-12R-beta-2, IL-12RB2,The Interleukin 12 Receptor Subunit Beta 2 encoded by IL12RB2 is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense. Several transcript variants encoding different isoforms and non-protein coding transcripts have been found for this gene.,I12R2
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分子量
- observerd band 94kDa
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基因ID
- 3595
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UniProt
- Q99665
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途径
- JAK/STAT Signaling
抗原
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