HCAR2 抗体 (AA 260-340)
Quick Overview for HCAR2 抗体 (AA 260-340) (ABIN7228866)
抗原
See all HCAR2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 260-340
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原理
- HCAR2 Polyclonal Antibody
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特异性
- The antibody detects endogenous levels of HCAR2 protein
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纯化方法
- The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen
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免疫原
- Synthesized peptide derived from part region of human HCAR2 protein at AA range: 260-340
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亚型
- IgG
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anti-Hydroxycarboxylic Acid Receptor 2 (HCAR2) (AA 82-94), (Extracellular) antibody
HCAR2 适用: 小鼠 IHC, WB, FACS, LCI 宿主: 兔 Polyclonal unconjugated
anti-Hydroxycarboxylic Acid Receptor 2 (HCAR2) (AA 250-350) antibodyHCAR2 适用: 人 IHC, WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Hydroxycarboxylic Acid Receptor 2 (HCAR2) antibodyHCAR2 适用: 人, 小鼠, 大鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Hydroxycarboxylic Acid Receptor 2 (HCAR2) (AA 82-94), (Extracellular) antibody (FITC)HCAR2 适用: 小鼠 FACS, LCI 宿主: 兔 Polyclonal FITC
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), ELISA (1:5000-1:20000).
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说明
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Primary Antibody
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- PBS, pH 7.4, containing 0.02 % Sodium Azide as preservative and 50 % Glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
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- HCAR2 (Hydroxycarboxylic Acid Receptor 2 (HCAR2))
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别名
- HCAR2
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背景
- Rabbit Anti-HCAR2 Polyclonal Antibody,Hydroxycarboxylic acid receptor 2, G-protein coupled receptor 109A, G-protein coupled receptor HM74A, Niacin receptor 1, Nicotinic acid receptor,Acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis. The rank order of potency for the displacement of nicotinic acid binding is 5-methyl pyrazole-3-carboxylic acid = pyridine-3-acetic acid > acifran > 5-methyl nicotinic acid = acipimox >> nicotinuric acid = nicotinamide.,HCAR2
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分子量
- observerd band 39kDa
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基因ID
- 338442
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UniProt
- Q8TDS4
抗原
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