GDNF 抗体 (AA 100-180)
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Quick Overview for GDNF 抗体 (AA 100-180) (ABIN7228642)
抗原
See all GDNF 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 100-180
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原理
- GDNF Polyclonal Antibody
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特异性
- The antibody detects endogenous levels of GDNF protein
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纯化方法
- The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen
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免疫原
- Synthesized peptide derived from part region of human GDNF protein at AA range: 100-180
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亚型
- IgG
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), ELISA (1:5000-1:20000).
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说明
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Primary Antibody
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- PBS, pH 7.4, containing 0.02 % Sodium Azide as preservative and 50 % Glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
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- GDNF (Glial Cell Line Derived Neurotrophic Factor (GDNF))
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别名
- GDNF
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背景
- Rabbit Anti-GDNF Polyclonal Antibody,Glial cell line-derived neurotrophic factor, hGDNF, Astrocyte-derived trophic factor, ATF,GDNF encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The recombinant form of this protein, a highly conserved neurotrophic factor, was shown to promote the survival and differentiation of dopaminergic neurons in culture, and was able to prevent apoptosis of motor neurons induced by axotomy. This protein is a ligand for the product of the RET (rearranged during transfection) protooncogene. Mutations in GDNF may be associated with Hirschsprung disease and Tourette syndrome. GDNF encodes multiple protein isoforms that may undergo similar proteolytic processing.,GDNF
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分子量
- observerd band 23kDa
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基因ID
- 2668
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UniProt
- P39905
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途径
- RTK signaling, Synaptic Membrane, Tube Formation, Autophagy, Smooth Muscle Cell Migration
抗原
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