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GDNF 抗体 (AA 100-180)

This 兔 多克隆 antibody specifically detects GDNF in WB 和 ELISA. It exhibits reactivity toward 人, 小鼠 和 大鼠.
产品编号 ABIN7228642
发货至: 中国
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Quick Overview for GDNF 抗体 (AA 100-180) (ABIN7228642)

抗原

See all GDNF 抗体
GDNF (Glial Cell Line Derived Neurotrophic Factor (GDNF))

适用

  • 83
  • 56
  • 45
  • 16
  • 16
  • 1
人, 小鼠, 大鼠

宿主

  • 80
  • 8
  • 3
  • 3
  • 1

克隆类型

  • 67
  • 25
  • 2
多克隆

标记

  • 50
  • 10
  • 4
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
This GDNF antibody is un-conjugated

应用范围

  • 80
  • 31
  • 27
  • 23
  • 13
  • 13
  • 10
  • 8
  • 6
  • 5
  • 5
  • 4
  • 3
  • 3
  • 1
  • 1
  • 1
Western Blotting (WB), ELISA
  • 抗原表位

    • 16
    • 9
    • 8
    • 4
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 100-180

    原理

    GDNF Polyclonal Antibody

    特异性

    The antibody detects endogenous levels of GDNF protein

    纯化方法

    The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen

    免疫原

    Synthesized peptide derived from part region of human GDNF protein at AA range: 100-180

    亚型

    IgG
  • 应用备注

    Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), ELISA (1:5000-1:20000).

    说明

    Primary Antibody

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    1 mg/mL

    缓冲液

    PBS, pH 7.4, containing 0.02 % Sodium Azide as preservative and 50 % Glycerol.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
  • 抗原

    GDNF (Glial Cell Line Derived Neurotrophic Factor (GDNF))

    别名

    GDNF

    背景

    Rabbit Anti-GDNF Polyclonal Antibody,Glial cell line-derived neurotrophic factor, hGDNF, Astrocyte-derived trophic factor, ATF,GDNF encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The recombinant form of this protein, a highly conserved neurotrophic factor, was shown to promote the survival and differentiation of dopaminergic neurons in culture, and was able to prevent apoptosis of motor neurons induced by axotomy. This protein is a ligand for the product of the RET (rearranged during transfection) protooncogene. Mutations in GDNF may be associated with Hirschsprung disease and Tourette syndrome. GDNF encodes multiple protein isoforms that may undergo similar proteolytic processing.,GDNF

    分子量

    observerd band 23kDa

    基因ID

    2668

    UniProt

    P39905

    途径

    RTK signaling, Synaptic Membrane, Tube Formation, Autophagy, Smooth Muscle Cell Migration
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