DAAM1 抗体 (AA 400-500)
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Quick Overview for DAAM1 抗体 (AA 400-500) (ABIN7228144)
抗原
See all DAAM1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 400-500
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原理
- DAAM1 Polyclonal Antibody
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特异性
- The antibody detects endogenous levels of DAAM1
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纯化方法
- The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen
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免疫原
- Synthesized peptide derived from part region of human DAAM1 protein at AA range: 400-500
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亚型
- IgG
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), ELISA (1:10000-1:20000).
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说明
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Primary Antibody
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- PBS, pH 7.4, containing 0.02 % Sodium Azide as preservative and 50 % Glycerol as stabilizer.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
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- DAAM1 (Dishevelled Associated Activator of Morphogenesis 1 (DAAM1))
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别名
- DAAM1
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背景
- Rabbit Anti-DAAM1 Polyclonal Antibody,Disheveled-associated activator of morphogenesis 1,Cell motility, adhesion, cytokinesis, and other functions of the cell cortex are mediated by reorganization of the actin cytoskeleton and several formin homology (FH) proteins have been associated with these processes. The protein encoded by DAAM1 contains two FH domains and belongs to a novel FH protein subfamily implicated in cell polarity. A key regulator of cytoskeletal architecture, the small GTPase Rho, is activated during development by Wnt/Fz signaling to control cell polarity and movement. The protein encoded by DAAM1 is thought to function as a scaffolding protein for the Wnt-induced assembly of a disheveled (Dvl)-Rho complex. This protein also promotes the nucleation and elongation of new actin filaments and regulates cell growth through the stabilization of microtubules. Alternative splicing results in multiple transcript variants encoding distinct proteins.,DAAM1
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分子量
- observerd band 123kDa
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基因ID
- 23002
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UniProt
- Q9Y4D1
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途径
- WNT signaling
抗原
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