ADAM17 抗体
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Quick Overview for ADAM17 抗体 (ABIN7224584)
抗原
See all ADAM17 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- TACE Polyclonal Antibody
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特异性
- TACE Polyclonal Antibody detects endogenous levels of TACE protein.
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
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免疫原
- Synthesized peptide derived from human TACE around the non-phosphorylation site of T735
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亚型
- IgG
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anti-ADAM Metallopeptidase Domain 17 (ADAM17) (AA 226-473) antibody
ADAM17 适用: 人 WB, IHC 宿主: 小鼠 Monoclonal C7 unconjugated
anti-ADAM Metallopeptidase Domain 17 (ADAM17) (AA 215-314) antibodyADAM17 适用: 人 WB, ELISA, IHC (p), PLA 宿主: 小鼠 Monoclonal 1F6 unconjugated
anti-ADAM Metallopeptidase Domain 17 (ADAM17) (AA 201-300) antibodyADAM17 适用: 人, 大鼠, 小鼠 WB, ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-ADAM Metallopeptidase Domain 17 (ADAM17) (AA 226-473) antibodyADAM17 适用: 人 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-ADAM Metallopeptidase Domain 17 (ADAM17) antibodyADAM17 适用: 人 WB, FACS, IF (p) 宿主: 兔 Monoclonal 25GB395 unconjugated Recombinant Antibody
anti-ADAM Metallopeptidase Domain 17 (ADAM17) (C-Term) antibodyVerified ADAM17 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-ADAM Metallopeptidase Domain 17 (ADAM17) (C-Term) antibodyKO Validated ADAM17 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-ADAM Metallopeptidase Domain 17 (ADAM17) antibodyADAM17 适用: 人, 大鼠, 小鼠 WB, FACS, IF (cc) 宿主: 兔 Monoclonal 9E7 unconjugated
anti-ADAM Metallopeptidase Domain 17 (ADAM17) (pThr735) antibodyADAM17 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-ADAM Metallopeptidase Domain 17 (ADAM17) (AA 215-315) antibodyADAM17 适用: 人 WB, ELISA, IHC, IHC (p), PLA 宿主: 小鼠 Monoclonal 1F6 unconjugated
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IF (1:200-1:1000), ELISA (1:5000). Not yet tested in other applications.
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说明
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Primary Antibody
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
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- ADAM17 (ADAM Metallopeptidase Domain 17 (ADAM17))
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别名
- TACE
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背景
- Rabbit Anti-TACE Polyclonal Antibody,ADAM17, CSVP, TACE, Disintegrin and metalloproteinase domain-containing protein 17, ADAM 17, Snake venom-like protease, TNF-alpha convertase, TNF-alpha-converting enzyme, CD antigen CD156b,ADAM17 (ADAM metallopeptidase domain 17) encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The encoded preproprotein is proteolytically processed to generate the mature protease. The encoded protease functions in the ectodomain shedding of tumor necrosis factor-alpha, in which soluble tumor necrosis factor-alpha is released from the membrane-bound precursor. This protease also functions in the processing of numerous other substrates, including cell adhesion proteins, cytokine and growth factor receptors and epidermal growth factor (EGF) receptor ligands. The encoded protein also plays a prominent role in the activation of the Notch signaling pathway. Elevated expression of ADAM17 has been observed in specific cell types derived from psoriasis, rheumatoid arthritis, multiple sclerosis and Crohn's disease patients, suggesting that the encoded protein may play a role in autoimmune disease.,Disintegrin and metalloproteinase domain-containing protein 17
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基因ID
- 6868
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UniProt
- P78536
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途径
- Notch Signaling, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Response to Growth Hormone Stimulus
抗原
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