Recombinant ErbB2/Her2 (Trastuzumab Biosimilar) 抗体
Quick Overview for Recombinant ErbB2/Her2 (Trastuzumab Biosimilar) 抗体 (ABIN7200659)
抗原
抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- Trastuzumab Biosimilar, HER2 Monoclonal Antibody
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特异性
- The monoclonal antibody trastuzumab biosimilar specifically binds to the human HER2 / ErbB-2 / c-neu.
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产品特性
- Recombinant Humanized IgG1 Monoclonal Antibody.
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纯化方法
- Protein A affinity column
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纯度
- > 95% by SDS-PAGE under reducing conditions and HPLC.
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过滤
- 0.2 μm filtered
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内毒素水平
- < 1 EU per 1 mg of the protein by the LAL method.
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免疫原
- The monoclonal antibody trastuzumab biosimilar was produced in the trastuzumab biosimilar CHO stable cell line.
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亚型
- IgG1 kappa
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anti-ErbB2/Her2 (Trastuzumab Biosimilar) antibody
Research Grade 适用: 人 FACS, ELISA 宿主: Humanized Monoclonal unconjugated Recombinant Antibody
anti-ErbB2/Her2 (Trastuzumab Biosimilar) antibody适用: 人 FACS, ELISA, IHC 宿主: 兔 Chimeric 4D5-8 unconjugated Recombinant Antibody
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应用备注
- ELISA, neutralization, functional assays such as bioanalytical PK and ADA assays, and those assays for studying biological pathways affected by trastuzumab.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 21.2 mg/mL
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缓冲液
- PBS, pH 7.4, no stabilizers or preservatives.
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储存液
- Without preservative
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注意事项
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- 12 months from date of receipt, -20 to -70°C as supplied. 1 month from date of receipt, 2 to 8°C as supplied.
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有效期
- 12 months
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- ErbB2/Her2 (Trastuzumab Biosimilar)
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物质类
- Biosimilar
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背景
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Trastuzumab, a humanized monoclonal antibody, interferes with the HER2/neu receptor and is mainly used to treat certain breast cancers, especially HER2-positive metastatic breast cancer. Combined with chemotherapy, trastuzumab increases both survival and response rate.
There are four closely related receptor tyrosine kinases in the ErbB family of receptors: EGFR (ErbB-1; HER1 in humans), HER2/c-neu (ErbB-2), Her 3 (ErbB-3) and Her 4 (ErbB-4). Bound by members of the epidermal growth factor family (EGF-family) of extracellular protein ligands, the HER receptors embedded in the cell membrane promote cell growth and division by turning genes on and off. The HER2 pathway stimulates cell proliferation if it normally functions; when HER2 is overexpressed, cell growth accelerates beyond its normal limits, which happens in some cancers, notably certain types of breast cancer.
抗原
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