Insulin Receptor 抗体 (AA 413-624)
Quick Overview for Insulin Receptor 抗体 (AA 413-624) (ABIN7193923)
抗原
See all Insulin Receptor (INSR) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
-
-
抗原表位
- AA 413-624
-
原理
- CD220 Antibody
-
纯化方法
- Purified antibody
-
免疫原
- Purified recombinant fragment of human CD220 (AA: 413-624) expressed in E. Coli.
-
亚型
- IgG2a
-
-
-
-
应用备注
-
ELISA: 1/10000
FCM: 1/200 - 1/400
ICC: 1/50 - 1/200
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
缓冲液
- Purified antibody in PBS with 0.05 % sodium azide.
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- 4 °C,-20 °C
-
储存方法
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
-
-
- Insulin Receptor (INSR)
-
别名
- CD220
-
背景
-
This gene encodes a member of the receptor tyrosine kinase family of proteins. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form a heterotetrameric receptor. Binding of insulin or other ligands to this receptor activates the insulin signaling pathway, which regulates glucose uptake and release, as well as the synthesis and storage of carbohydrates, lipids and protein. Mutations in this gene underlie the inherited severe insulin resistance syndromes including type A insulin resistance syndrome, Donohue syndrome and Rabson-Mendenhall syndrome. Alternative splicing results in multiple transcript variants.
-
分子量
- 156 kDa
-
基因ID
- 3643
-
UniProt
- P06213
-
途径
- NF-kappaB Signaling, RTK signaling, AMPK Signaling, Carbohydrate Homeostasis, Regulation of Cell Size, Regulation of Carbohydrate Metabolic Process, Growth Factor Binding, Negative Regulation of Transporter Activity
抗原
-