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Cyclin E1 抗体 (AA 1-100)

This anti-Cyclin E1 antibody is a 小鼠 单克隆 antibody detecting Cyclin E1 in IHC, ELISA 和 FACS. Suitable for 人.
产品编号 ABIN7193589
发货至: 中国

Quick Overview for Cyclin E1 抗体 (AA 1-100) (ABIN7193589)

抗原

See all Cyclin E1 (CCNE1) 抗体
Cyclin E1 (CCNE1)

适用

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宿主

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小鼠

克隆类型

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单克隆

标记

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This Cyclin E1 antibody is un-conjugated

应用范围

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Immunohistochemistry (IHC), ELISA, Flow Cytometry (FACS)

克隆位点

1C8D4
  • 抗原表位

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    AA 1-100

    原理

    CCNE1 Antibody

    纯化方法

    Purified antibody

    免疫原

    Purified recombinant fragment of human CCNE1 (AA: 1-100) expressed in E. Coli.

    亚型

    IgG1
  • 应用备注

    ELISA: 1/10000

    FCM: 1/200-1/400

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    Purified antibody in PBS with 0.05 % sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    储存方法

    Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
  • 抗原

    Cyclin E1 (CCNE1)

    别名

    CCNE1

    背景

    The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. [provided by RefSeq, Apr 2016]

    分子量

    47 kDa

    基因ID

    898

    UniProt

    P24864

    途径

    Cell Division Cycle, Intracellular Steroid Hormone Receptor Signaling Pathway, Nuclear Hormone Receptor Binding, Mitotic G1-G1/S Phases
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