MTA1 抗体 (AA 541-715)
Quick Overview for MTA1 抗体 (AA 541-715) (ABIN7193370)
抗原
See all MTA1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 541-715
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原理
- MTA1 Antibody
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纯化方法
- Purified antibody
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免疫原
- Purified recombinant fragment of human MTA1 (AA: 541-715) expressed in E. Coli.
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亚型
- IgG2b
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应用备注
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ELISA: 1/10000
FCM: 1/200 - 1/400
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Purified antibody in PBS with 0.05 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
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- MTA1 (Metastasis Associated 1 (MTA1))
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别名
- MTA1
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背景
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This gene encodes a protein that was identified in a screen for genes expressed in metastatic cells, specifically, mammary adenocarcinoma cell lines. Expression of this gene has been correlated with the metastatic potential of at least two types of carcinomas although it is also expressed in many normal tissues. The role it plays in metastasis is unclear. It was initially thought to be the 70kD component of a nucleosome remodeling deacetylase complex, NuRD, but it is more likely that this component is a different but very similar protein. These two proteins are so closely related, though, that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. The profile and activity of this gene product suggest that it is involved in regulating transcription and that this may be accomplished by chromatin remodeling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]
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分子量
- 80.8 kDa
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基因ID
- 9112
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UniProt
- Q13330
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途径
- Chromatin Binding
抗原
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