LRP6 抗体 (AA 1198-1370)
Quick Overview for LRP6 抗体 (AA 1198-1370) (ABIN7193277)
抗原
See all LRP6 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 1198-1370
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原理
- LRP6 Antibody
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纯化方法
- Purified antibody
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免疫原
- Purified recombinant fragment of human LRP6 (AA: 1198-1370) expressed in E. Coli.
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亚型
- IgG1
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应用备注
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ELISA: 1/10000
FCM: 1/200 - 1/400
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Purified antibody in PBS with 0.05 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
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- LRP6 (Low Density Lipoprotein Receptor-Related Protein 6 (LRP6))
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别名
- LRP6
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背景
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This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined.
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分子量
- 180 kDa
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UniProt
- O75581
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途径
- WNT signaling, Tube Formation
抗原
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