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H2AFX 抗体 (AA 130-142)

This 兔 多克隆 anti-H2AFX antibody specifically detects H2AFX in IHC 和 ELISA. The antibody is reactive with 人 samples.
产品编号 ABIN7181497
发货至: 中国
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Quick Overview for H2AFX 抗体 (AA 130-142) (ABIN7181497)

抗原

See all H2AFX 抗体
H2AFX (H2A Histone Family, Member X (H2AFX))

适用

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宿主

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克隆类型

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多克隆

标记

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This H2AFX antibody is un-conjugated

应用范围

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Immunohistochemistry (IHC), ELISA
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    AA 130-142

    原理

    H2AFX (Ab-142) Antibody

    纯化方法

    Antigen Affinity Purified

    免疫原

    Synthesized peptide derived from Human Histone H2AX protein (130-142aa)

    亚型

    IgG
  • 应用备注

    Optimal working dilution should be determined by the investigator.

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

    储存液

    ProClin

    注意事项

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C,-80 °C

    储存方法

    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 抗原

    H2AFX (H2A Histone Family, Member X (H2AFX))

    别名

    H2AFX

    背景

    Background: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation.

    Aliases: Histone H2AX (H2a/x) (Histone H2A.X), H2AFX, H2AX

    UniProt

    P16104

    途径

    Telomere Maintenance, DNA Damage Repair, Positive Regulation of Response to DNA Damage Stimulus
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