TGFB1 抗体 (AA 30-278)
Quick Overview for TGFB1 抗体 (AA 30-278) (ABIN7177931)
抗原
See all TGFB1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 30-278
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交叉反应
- 人, 小鼠
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纯化方法
- >95%, Protein G purified
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免疫原
- Recombinant Mouse Transforming growth factor beta-1 protein (30-278AA)
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亚型
- IgG
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anti-Transforming Growth Factor, beta 1 (TGFB1) (C-Term) antibody
TGFB1 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Transforming Growth Factor, beta 1 (TGFB1) (AA 279-390) antibodyTGFB1 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Transforming Growth Factor, beta 1 (TGFB1) (AA 62-195) antibodyTGFB1 适用: 人 IHC, ELISA, FACS 宿主: 小鼠 Monoclonal 7F6 unconjugated
anti-Transforming Growth Factor, beta 1 (TGFB1) (AA 351-390) antibodyTGFB1 适用: 人, 小鼠, 大鼠, 绵羊, 兔 WB, ELISA, FACS, IHC (p), IF (p), IF (cc), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Transforming Growth Factor, beta 1 (TGFB1) (Middle Region) antibodyTGFB1 适用: 小鼠, 大鼠, Cow, Pig, 绵羊, 豚鼠, 犬, 马, 山羊 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Transforming Growth Factor, beta 1 (TGFB1) (AA 62-195) antibodyTGFB1 适用: 人 WB, IHC, ELISA, FACS 宿主: 小鼠 Monoclonal unconjugated
anti-Transforming Growth Factor, beta 1 (TGFB1) (AA 279-390) antibodyTGFB1 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Transforming Growth Factor, beta 1 (TGFB1) (N-Term) antibodyTGFB1 适用: 人 WB, ELISA, FM 宿主: 兔 Polyclonal unconjugated
anti-Transforming Growth Factor, beta 1 (TGFB1) (C-Term) antibodyTGFB1 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Transforming Growth Factor, beta 1 (TGFB1) (AA 279-390) antibodyTGFB1 适用: 大鼠 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal D11 unconjugated
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应用备注
- Recommended dilution: WB:1:500-1:5000, IP:1:200-1:2000,
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 -
储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- TGFB1 (Transforming Growth Factor, beta 1 (TGFB1))
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别名
- Tgfb1
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背景
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Background: Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts. Can promote either T-helper 17 cells (Th17) or regulatory T-cells (Treg) lineage differentiation in a concentration-dependent manner. At high concentrations, leads to FOXP3-mediated suppression of RORC and down-regulation of IL-17 expression, favoring Treg cell development. At low concentrations in concert with IL-6 and IL-21, leads to expression of the IL-17 and IL-23 receptors, favoring differentiation to Th17 cells (PubMed:18368049). Mediates SMAD2/3 activation by inducing its phosphorylation and subsequent translocation to the nucleus. Can induce epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types (By similarity).
Aliases: Tgfb1 antibody, Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide antibody, LAP), Transforming growth factor beta-1 antibody, TGF-beta-1)] antibody
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UniProt
- P04202
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途径
- EGFR Signaling Pathway, Dopaminergic Neurogenesis, Cellular Response to Molecule of Bacterial Origin, Glycosaminoglycan Metabolic Process, Regulation of Leukocyte Mediated Immunity, Regulation of Muscle Cell Differentiation, Positive Regulation of Immune Effector Process, Cell-Cell Junction Organization, Production of Molecular Mediator of Immune Response, Ribonucleoside Biosynthetic Process, Skeletal Muscle Fiber Development, Regulation of Carbohydrate Metabolic Process, Protein targeting to Nucleus, Autophagy, Cancer Immune Checkpoints
抗原
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