VEGFR2/CD309 抗体 (AA 20-764)
Quick Overview for VEGFR2/CD309 抗体 (AA 20-764) (ABIN7175384)
抗原
See all VEGFR2/CD309 (VEGFR2) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 20-764
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交叉反应
- 人
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纯化方法
- >95%, Protein G purified
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免疫原
- Recombinant Human Vascular endothelial growth factor receptor 2 protein (20-764AA)
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亚型
- IgG
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anti-VEGF Receptor 2 (VEGFR2) (AA 20-200) antibody
VEGFR2 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-VEGF Receptor 2 (VEGFR2) (pTyr951) antibodyVEGFR2 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-VEGF Receptor 2 (VEGFR2) (AA 20-242) antibodyVEGFR2 适用: 人 WB, IHC, FACS, ICC 宿主: 兔 Polyclonal unconjugated
anti-VEGF Receptor 2 (VEGFR2) (AA 1326-1356) antibodyVEGFR2 适用: 人 WB, IHC, ELISA, FACS, IF 宿主: 兔 Polyclonal unconjugated
anti-VEGF Receptor 2 (VEGFR2) (AA 101-200) antibodyVEGFR2 适用: 人, 小鼠, 大鼠, 兔 ELISA, FACS, IHC (p), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-VEGF Receptor 2 (VEGFR2) (pTyr1214) antibodyVEGFR2 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-VEGF Receptor 2 (VEGFR2) (AA 20-764) antibodyVEGFR2 适用: 人 ELISA, FACS, ICC 宿主: 小鼠 Monoclonal 4B4 unconjugated
anti-VEGF Receptor 2 (VEGFR2) (AA 1225-1356) antibodyVEGFR2 适用: 人 ELISA, FACS 宿主: 小鼠 Monoclonal 1A9A3 unconjugated
anti-VEGF Receptor 2 (VEGFR2) (AA 454-469), (Middle Region) antibodyVEGFR2 适用: 人 WB, IHC, ICC 宿主: 兔 Polyclonal unconjugated
anti-VEGF Receptor 2 (VEGFR2) (AA 1326-1356), (C-Term) antibodyVEGFR2 适用: 人 WB, FACS, IF, IHC (p) 宿主: 兔 Polyclonal RB01536 unconjugated
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应用备注
- Recommended dilution: IHC:1:20-1:200,
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 -
储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- VEGFR2/CD309 (VEGFR2) (VEGF Receptor 2 (VEGFR2))
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别名
- KDR
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背景
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Background: Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFC and VEGFD. Plays an essential role in the regulation of angiogenesis, vascular development, vascular permeability, and embryonic hematopoiesis. Promotes proliferation, survival, migration and differentiation of endothelial cells. Promotes reorganization of the actin cytoskeleton. Isoforms lacking a transmembrane domain, such as isoform 2 and isoform 3, may function as decoy receptors for VEGFA, VEGFC and/or VEGFD. Isoform 2 plays an important role as negative regulator of VEGFA- and VEGFC-mediated lymphangiogenesis by limiting the amount of free VEGFA and/or VEGFC and preventing their binding to FLT4. Modulates FLT1 and FLT4 signaling by forming heterodimers. Binding of vascular growth factors to isoform 1 leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, reorganization of the actin cytoskeleton and activation of PTK2/FAK1. Required for VEGFA-mediated induction of NOS2 and NOS3, leading to the production of the signaling molecule nitric oxide (NO) by endothelial cells. Phosphorylates PLCG1. Promotes phosphorylation of FYN, NCK1, NOS3, PIK3R1, PTK2/FAK1 and SRC.
Aliases: CD309 antibody, CD309 antigen antibody, EC 2.7.10.1 antibody, Fetal liver kinase 1 antibody, FLK-1 antibody, FLK1 antibody, FLK1, mouse, homolog of antibody, Kdr antibody, Kinase insert domain receptor (a type III receptor tyrosine kinase) antibody, Kinase insert domain receptor antibody, KRD1 antibody, Ly73 antibody, Protein tyrosine kinase receptor FLK1 antibody, Protein-tyrosine kinase receptor flk-1 antibody, soluble VEGFR2 antibody, Tyrosine kinase growth factor receptor antibody, Vascular endothelial growth factor receptor 2 antibody, VEGFR 2 antibody, VEGFR antibody, VEGFR-2 antibody, VEGFR2 antibody, VGFR2_HUMAN antibody
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UniProt
- P35968
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途径
- RTK signaling, Glycosaminoglycan Metabolic Process, Signaling Events mediated by VEGFR1 and VEGFR2, Growth Factor Binding, Regulation of long-term Neuronal Synaptic Plasticity, VEGF Signaling
抗原
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