TAO Kinase 2 抗体 (AA 719-880) (Biotin)
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北京 101111
Quick Overview for TAO Kinase 2 抗体 (AA 719-880) (Biotin) (ABIN7169192)
抗原
See all TAO Kinase 2 (TAOK2) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 719-880
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原理
- TAOK2 Antibody, Biotin conjugated
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纯化方法
- Protein G purified
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纯度
- >95 %
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免疫原
- Recombinant Human Serine/threonine-protein kinase TAO2 protein (719-880AA)
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亚型
- IgG
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anti-TAO Kinase 2 (TAOK2) (AA 831-931) antibody
TAOK2 适用: 人 WB, ELISA, IHC, IHC (p) 宿主: 小鼠 Monoclonal 2E2 unconjugated
anti-TAO Kinase 2 (TAOK2) (AA 831-930) antibodyTAOK2 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 2E2 unconjugated
anti-TAO Kinase 2 (TAOK2) (AA 831-930) antibodyTAOK2 适用: 人 WB, ELISA, IF, PLA 宿主: 小鼠 Monoclonal 2F4 unconjugated
anti-TAO Kinase 2 (TAOK2) (AA 610-730) antibodyTAOK2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-TAO Kinase 2 (TAOK2) (AA 719-880) antibodyTAOK2 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-TAO Kinase 2 (TAOK2) (pSer181) antibodyTAOK2 适用: 人, 小鼠, 大鼠, 犬, 非洲爪蟾 WB, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 -
储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- TAO Kinase 2 (TAOK2)
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别名
- TAOK2
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背景
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Background: Serine/threonine-protein kinase involved in different processes such as membrane blebbing and apoptotic bodies formation DNA damage response and MAPK14/p38 MAPK stress-activated MAPK cascade. Phosphorylates itself, MBP, activated MAPK8, MAP2K3, MAP2K6 and tubulins. Activates the MAPK14/p38 MAPK signaling pathway through the specific activation and phosphorylation of the upstream MAP2K3 and MAP2K6 kinases. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Isoform 1, but not isoform 2, plays a role in apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation. This function, which requires the activation of MAPK8/JNK and nuclear localization of C-terminally truncated isoform 1, may be linked to the mitochondrial CASP9-associated death pathway. Isoform 1 binds to microtubules and affects their organization and stability independently of its kinase activity. Prevents MAP3K7-mediated activation of CHUK, and thus NF-kappa-B activation, but not that of MAPK8/JNK. May play a role in the osmotic stress-MAPK8 pathway. Isoform 2, but not isoform 1, is required for PCDH8 endocytosis. Following homophilic interactions between PCDH8 extracellular domains, isoform 2 phosphorylates and activates MAPK14/p38 MAPK which in turn phosphorylates isoform 2. This process leads to PCDH8 endocytosis and CDH2 cointernalization. Both isoforms are involved in MAPK14 phosphorylation.
Aliases: 1110033K02Rik antibody, B230344N16 antibody, hKFC C antibody, hKFC-C antibody, KIAA0881 antibody, Kinase from chicken homolog C antibody, MAP3K17 antibody, mKIAA0881 antibody, Prostate derived STE20 like kinase 1 antibody, Prostate derived STE20 like kinase PSK antibody, Prostate derived sterile 20 like kinase 1 antibody, Prostate-derived STE20-like kinase 1 antibody, PSK 1 antibody, PSK antibody, PSK-1 antibody, PSK1 antibody, PSK1 beta antibody, Serine/threonine protein kinase TAO2 antibody, Serine/threonine-protein kinase TAO2 antibody, TAO 1 antibody, TAO 2 antibody, TAO kinase 2 antibody, TAO1 antibody, TAO2 antibody, TAOK 2 antibody, Taok2 antibody, TAOK2_HUMAN antibody, Thousand and one amino acid protein 2 antibody, Thousand and one amino acid protein kinase antibody, UNQ2971/PRO7431 antibody
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UniProt
- Q9UL54
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途径
- Cell-Cell Junction Organization
抗原
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