PINK1 抗体 (AA 162-272)
Quick Overview for PINK1 抗体 (AA 162-272) (ABIN7169153)
抗原
See all PINK1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 162-272
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交叉反应
- 人
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纯化方法
- >95%, Protein G purified
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免疫原
- Recombinant Human Serine/threonine-protein kinase PINK1, mitochondrial protein (162-272AA)
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亚型
- IgG
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应用备注
- Recommended dilution: IHC:1:20-1:200,
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 -
储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- PINK1 (PTEN Induced Putative Kinase 1 (PINK1))
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别名
- PINK1
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背景
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Background: Protects against mitochondrial dysfunction during cellular stress by phosphorylating mitochondrial proteins. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy) by mediating activation and translocation of PARK2. Targets PARK2 to dysfunctional depolarized mitochondria through the phosphorylation of MFN2. Activates PARK2 in 2 steps: (1) by mediating phosphorylation at \\\'Ser-65\\\' of PARK2 and (2) mediating phosphorylation of ubiquitin, converting PARK2 to its fully-active form (PubMed:24660806, PubMed:24751536, PubMed:24784582, PubMed:25527291).
Aliases: BRPK antibody, FLJ27236 antibody, mitochondrial antibody, PARK 6 antibody, PARK6 antibody, Phosphatase and Tensin Homolog antibody, PINK 1 antibody, PINK1 antibody, PINK1_HUMAN antibody, Protein kinase BRPK antibody, PTEN induced putative kinase 1 antibody, PTEN induced putative kinase protein 1 antibody, PTEN-induced putative kinase protein 1 antibody, Serine/threonine kinase PINK1 mitochondrial antibody, Serine/threonine protein kinase PINK1 mitochondrial antibody, Serine/threonine-protein kinase PINK1 antibody
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UniProt
- Q9BXM7
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途径
- Autophagy
抗原
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