PPIF 抗体 (AA 30-207)
Quick Overview for PPIF 抗体 (AA 30-207) (ABIN7162809)
抗原
See all PPIF 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 30-207
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交叉反应
- 人
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纯化方法
- Antigen Affinity Purified
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免疫原
- Recombinant Human Peptidyl-prolyl cis-trans isomerase F, mitochondrial protein (30-207AA)
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亚型
- IgG
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应用备注
- Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200,
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- PPIF (Peptidylprolyl Isomerase F (PPIF))
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别名
- PPIF
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背景
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Background: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Involved in regulation of the mitochondrial permeability transition pore (mPTP). It is proposed that its association with the mPTP is masking a binding site for inhibiting inorganic phosphate (Pi) and promotes the open probability of the mPTP leading to apoptosis or necrosis, the requirement of the PPIase activity for this function is debated. In cooperation with mitochondrial TP53 is involved in activating oxidative stress-induced necrosis. Involved in modulation of mitochondrial membrane F(1)F(0) ATP synthase activity and regulation of mitochondrial matrix adenine nucleotide levels. Has anti-apoptotic activity independently of mPTP and in cooperation with BCL2 inhibits cytochrome c-dependent apoptosis.
Aliases: Cyclophilin 3 antibody, cyclophilin D antibody, Cyclophilin F antibody, Cyp D antibody, CyP M antibody, CyP-D antibody, CyP-M antibody, CYP3 antibody, CypD antibody, hCyP3 antibody, mitochondrial antibody, Mitochondrial cyclophilin antibody, Peptidyl prolyl cis trans isomerase, mitochondral antibody, Peptidyl-prolyl cis-trans isomerase F antibody, Peptidyl-prolyl cis-trans isomerase F, mitochondrial antibody, Peptidylprolyl isomerase F (cyclophilin F) antibody, Peptidylprolyl isomerase F antibody, PPIase antibody, PPIase F antibody, Ppif antibody, PPIF_HUMAN antibody, Rotamase antibody, Rotamase F antibody
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UniProt
- P30405
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途径
- Proton Transport, Negative Regulation of intrinsic apoptotic Signaling, Negative Regulation of Transporter Activity
抗原
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