MAPKAP Kinase 5 抗体 (AA 200-471)
Quick Overview for MAPKAP Kinase 5 抗体 (AA 200-471) (ABIN7158992)
抗原
See all MAPKAP Kinase 5 (MAPKAPK5) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 200-471
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交叉反应
- 人
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纯化方法
- >95%, Protein G purified
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免疫原
- Recombinant Human MAP kinase-activated protein kinase 5 protein (200-471AA)
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亚型
- IgG
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anti-Mitogen-Activated Protein Kinase-Activated Protein Kinase 5 (MAPKAPK5) (pThr182) antibody
MAPKAPK5 适用: 大鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase-Activated Protein Kinase 5 (MAPKAPK5) (AA 371-471) antibodyMAPKAPK5 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 3D7 unconjugated
anti-Mitogen-Activated Protein Kinase-Activated Protein Kinase 5 (MAPKAPK5) (pThr182) antibodyMAPKAPK5 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase-Activated Protein Kinase 5 (MAPKAPK5) antibodyMAPKAPK5 适用: 人 ELISA, IHC 宿主: 小鼠 Monoclonal 7H10B4 unconjugated
anti-Mitogen-Activated Protein Kinase-Activated Protein Kinase 5 (MAPKAPK5) (pSer93) antibodyMAPKAPK5 适用: 人, 小鼠, 大鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase-Activated Protein Kinase 5 (MAPKAPK5) (Internal Region) antibodyVerified MAPKAPK5 适用: 人, 小鼠 WB, ELISA, IHC, IP 宿主: 山羊 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase-Activated Protein Kinase 5 (MAPKAPK5) (AA 1-471) antibodyMAPKAPK5 适用: 人 WB, PLA 宿主: 兔 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase-Activated Protein Kinase 5 (MAPKAPK5) (AA 1-471) antibodyMAPKAPK5 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase-Activated Protein Kinase 5 (MAPKAPK5) (AA 371-471) antibodyMAPKAPK5 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2D5 unconjugated
anti-Mitogen-Activated Protein Kinase-Activated Protein Kinase 5 (MAPKAPK5) (AA 1-471) antibodyMAPKAPK5 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
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应用备注
- Recommended dilution: IF:1:200-1:500,
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 -
储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- MAPKAP Kinase 5 (MAPKAPK5) (Mitogen-Activated Protein Kinase-Activated Protein Kinase 5 (MAPKAPK5))
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别名
- MAPKAPK5
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背景
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Background: Tumor suppressor serine/threonine-protein kinase involved in mTORC1 signaling and post-transcriptional regulation. Phosphorylates FOXO3, ERK3/MAPK6, ERK4/MAPK4, HSP27/HSPB1, p53/TP53 and RHEB. Acts as a tumor suppressor by mediating Ras-induced senescence and phosphorylating p53/TP53. Involved in post-transcriptional regulation of MYC by mediating phosphorylation of FOXO3: phosphorylation of FOXO3 leads to promote nuclear localization of FOXO3, enabling expression of miR-34b and miR-34c, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent MYC translation. Acts as a negative regulator of mTORC1 signaling by mediating phosphorylation and inhibition of RHEB. Part of the atypical MAPK signaling via its interaction with ERK3/MAPK6 or ERK4/MAPK4: the precise role of the complex formed with ERK3/MAPK6 or ERK4/MAPK4 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPK (ERK3/MAPK6 or ERK4/MAPK4), ERK3/MAPK6 (or ERK4/MAPK4) is phosphorylated and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6 (or ERK4/MAPK4). Mediates phosphorylation of HSP27/HSPB1 in response to PKA/PRKACA stimulation, inducing F-actin rearrangement.
Aliases: MAP kinase-activated protein kinase 5 antibody, MAPK-activated protein kinase 5 antibody, MAPK5_HUMAN antibody, MAPKAP kinase 5 antibody, MAPKAPK-5 antibody, MAPKAPK5 antibody, Mitogen activated protein kinase activated protein kinase 5 antibody, p38-regulated/activated protein kinase antibody, PRAK antibody
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UniProt
- Q8IW41
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途径
- MAPK Pathway
抗原
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