MAPKAP Kinase 5 抗体 (pThr182)
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- 抗原 See all MAPKAP Kinase 5 (MAPKAPK5) 抗体
- MAPKAP Kinase 5 (MAPKAPK5) (Mitogen-Activated Protein Kinase-Activated Protein Kinase 5 (MAPKAPK5))
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抗原表位
- pThr182
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适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This MAPKAP Kinase 5 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
- 特异性
- Phospho-MAPKAPK5 (Thr182) Antibody detects endogenous levels of MAPKAPK5 only when phosphorylated at Threonine 182.
- 纯化方法
- The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
- 免疫原
- A synthesized peptide derived from human MAPKAPK5 around the phosphorylation site of Thr182.
- 亚型
- IgG
- Top Product
- Discover our top product MAPKAPK5 Primary Antibody
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anti-Mitogen-Activated Protein Kinase-Activated Protein Kinase 5 (MAPKAPK5) (pThr182) antibody
MAPKAPK5 适用: 大鼠 WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase-Activated Protein Kinase 5 (MAPKAPK5) (AA 371-471) antibodyMAPKAPK5 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 3D7 unconjugated
anti-Mitogen-Activated Protein Kinase-Activated Protein Kinase 5 (MAPKAPK5) antibodyMAPKAPK5 适用: 人 WB, ELISA, IHC 宿主: 小鼠 Monoclonal 7H10B4 unconjugated
anti-Mitogen-Activated Protein Kinase-Activated Protein Kinase 5 (MAPKAPK5) (pSer93) antibodyMAPKAPK5 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase-Activated Protein Kinase 5 (MAPKAPK5) (AA 1-471) antibodyMAPKAPK5 适用: 人 WB, PLA 宿主: 兔 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase-Activated Protein Kinase 5 (MAPKAPK5) (AA 1-471) antibodyMAPKAPK5 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase-Activated Protein Kinase 5 (MAPKAPK5) (AA 371-471) antibodyMAPKAPK5 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2D5 unconjugated
anti-Mitogen-Activated Protein Kinase-Activated Protein Kinase 5 (MAPKAPK5) (AA 1-471) antibodyMAPKAPK5 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase-Activated Protein Kinase 5 (MAPKAPK5) (Internal Region) antibodyVerified MAPKAPK5 适用: 人, 小鼠 WB, ELISA, IHC, IP 宿主: 山羊 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase-Activated Protein Kinase 5 (MAPKAPK5) antibodyMAPKAPK5 适用: 人 WB, IF, ICC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
- 有效期
- 12 months
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- 抗原
- MAPKAP Kinase 5 (MAPKAPK5) (Mitogen-Activated Protein Kinase-Activated Protein Kinase 5 (MAPKAPK5))
- 别名
- MAPKAPK5 (MAPKAPK5 产品)
- 别名
- MAPKAPK5 antibody, MK5 antibody, PRAK antibody, MAPKAP-K5 antibody, MK-5 antibody, mitogen-activated protein kinase-activated protein kinase 5 antibody, MAP kinase-activated protein kinase 5 antibody, MAPKAPK5 antibody, mapkapk5 antibody, Mapkapk5 antibody
- 背景
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Description: Tumor suppressor serine/threonine-protein kinase involved in mTORC1 signaling and post-transcriptional regulation. Phosphorylates FOXO3, ERK3/MAPK6, ERK4/MAPK4, HSP27/HSPB1, p53/TP53 and RHEB. Acts as a tumor suppressor by mediating Ras-induced senescence and phosphorylating p53/TP53. Involved in post-transcriptional regulation of MYC by mediating phosphorylation of FOXO3: phosphorylation of FOXO3 leads to promote nuclear localization of FOXO3, enabling expression of miR-34b and miR-34c, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent MYC translation. Acts as a negative regulator of mTORC1 signaling by mediating phosphorylation and inhibition of RHEB. Part of the atypical MAPK signaling via its interaction with ERK3/MAPK6 or ERK4/MAPK4: the precise role of the complex formed with ERK3/MAPK6 or ERK4/MAPK4 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPK (ERK3/MAPK6 or ERK4/MAPK4), ERK3/MAPK6 (or ERK4/MAPK4) is phosphorylated and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6 (or ERK4/MAPK4). Mediates phosphorylation of HSP27/HSPB1 in response to PKA/PRKACA stimulation, inducing F-actin rearrangement.
Gene: MAPKAPK5
- 分子量
- 60kDa
- 基因ID
- 8550
- UniProt
- Q8IW41
- 途径
- MAPK Pathway
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