IL1RAP 抗体 (AA 21-356)
Quick Overview for IL1RAP 抗体 (AA 21-356) (ABIN7156734)
抗原
See all IL1RAP 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 21-356
-
交叉反应
- 人
-
纯化方法
- Antigen Affinity Purified
-
免疫原
- Recombinant Human Interleukin-1 receptor accessory protein (21-356AA)
-
亚型
- IgG
-
-
-
-
应用备注
- Recommended dilution: IHC:1:20-1:200,
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
缓冲液
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C,-80 °C
-
储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
-
-
- IL1RAP (Interleukin 1 Receptor Accessory Protein (IL1RAP))
-
别名
- IL1RAP
-
背景
-
Background: Coreceptor for IL1RL2 in the IL-36 signaling system (By similarity). Coreceptor with IL1R1 in the IL-1 signaling system. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone, binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non-signaling association with the membrane IL1R2 decoy receptor. Secreted forms (isoforms 2 and 3) associate with secreted ligand-bound IL1R2 and increase the affinity of secreted IL1R2 for IL1B, this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors.
Aliases: C3orf13 antibody, FLJ37788 antibody, IL 1 receptor accessory protein antibody, IL 1R 3 antibody, IL 1R3 antibody, IL 1RAcP antibody, IL 1RAP antibody, IL-1 receptor accessory protein antibody, IL-1R-3 antibody, IL-1R3 antibody, IL-1RAcP antibody, IL-1RAP antibody, IL1 receptor accessory protein antibody, IL1AP_HUMAN antibody, IL1R3 antibody, IL1RAcP antibody, Il1rap antibody, Interleukin 1 Accessory Protein antibody, interleukin 1 receptor 3 antibody, Interleukin 1 receptor accessory protein antibody, interleukin 1 receptor accessory protein beta antibody, Interleukin-1 receptor 3 antibody, Interleukin-1 receptor accessory protein antibody
-
UniProt
- Q9NPH3
-
途径
- NF-kappaB Signaling, Growth Factor Binding
抗原
-