H2AFX 抗体 (AA 12-141) (HRP)
Quick Overview for H2AFX 抗体 (AA 12-141) (HRP) (ABIN7155390)
抗原
See all H2AFX 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 12-141
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交叉反应
- 人
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纯化方法
- >95%, Protein G purified
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免疫原
- Recombinant Human Histone H2AX protein (12-141AA)
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亚型
- IgG
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 -
储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- H2AFX (H2A Histone Family, Member X (H2AFX))
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别名
- H2AFX
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背景
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Background: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation.
Aliases: H2A histone family member X antibody, H2A histone family member X antibody, H2A.FX antibody, H2A.X antibody, H2a/x antibody, H2AFX antibody, H2AX antibody, H2AX_HUMAN antibody, Histone H2A.X antibody
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UniProt
- P16104
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途径
- Telomere Maintenance, DNA Damage Repair, Positive Regulation of Response to DNA Damage Stimulus
抗原
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