RNF4 抗体 (AA 1-103) (Biotin)
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北京 101111
Quick Overview for RNF4 抗体 (AA 1-103) (Biotin) (ABIN7151195)
抗原
See all RNF4 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-103
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原理
- RNF4 Antibody, Biotin conjugated
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纯化方法
- Protein G purified
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纯度
- >95 %
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免疫原
- Recombinant Human E3 ubiquitin-protein ligase RNF4 protein (1-103AA)
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亚型
- IgG
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anti-Ring Finger Protein 4 (RNF4) (AA 1-103) antibody
RNF4 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Ring Finger Protein 4 (RNF4) (AA 1-190) antibodyRNF4 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Ring Finger Protein 4 (RNF4) (AA 107-190) antibodyRNF4 适用: 人 ELISA, WB 宿主: 小鼠 Polyclonal unconjugated
anti-Ring Finger Protein 4 (RNF4) (AA 95-123) antibodyRNF4 适用: 人 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Ring Finger Protein 4 (RNF4) (AA 94-123), (C-Term) antibodyRNF4 适用: 人 WB, EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 -
储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- RNF4 (Ring Finger Protein 4 (RNF4))
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别名
- RNF4
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背景
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Background: E3 ubiquitin-protein ligase which binds polysumoylated chains covalently attached to proteins and mediates \'Lys-6\'-, \'Lys-11\'-, \'Lys-48\'- and \'Lys-63\'-linked polyubiquitination of those substrates and their subsequent targeting to the proteasome for degradation. Regulates the degradation of several proteins including PML and the transcriptional activator PEA3. Involved in chromosome alignment and spindle assembly, it regulates the kinetochore CENPH-CENPI-CENPK complex by targeting polysumoylated CENPI to proteasomal degradation. Regulates the cellular responses to hypoxia and heat shock through degradation of respectively EPAS1 and PARP1. Alternatively, it may also bind DNA/nucleosomes and have a more direct role in the regulation of transcription for instance enhancing basal transcription and steroid receptor-mediated transcriptional activation.
Aliases: E3 ubiquitin ligase RNF4 antibody, E3 ubiquitin protein ligase RNF4 antibody, Protein SNURF antibody, RES4 26 antibody, RING finger protein 4 antibody, Rnf4 antibody, RNF4_HUMAN antibody, SLX5 antibody, Small nuclear ring finger protein antibody, SNURF antibody
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UniProt
- P78317
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途径
- Intracellular Steroid Hormone Receptor Signaling Pathway
抗原
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