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RNF4 抗体 (AA 1-103) (HRP)

RNF4 适用: 人 ELISA 宿主: 兔 Polyclonal HRP
产品编号 ABIN7151197
发货至: 中国
  • 抗原 See all RNF4 抗体
    RNF4 (Ring Finger Protein 4 (RNF4))
    抗原表位
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    AA 1-103
    适用
    • 18
    • 3
    • 2
    宿主
    • 17
    • 2
    克隆类型
    • 18
    • 1
    多克隆
    标记
    • 13
    • 3
    • 2
    • 1
    This RNF4 antibody is conjugated to HRP
    应用范围
    • 10
    • 9
    • 4
    • 2
    • 1
    • 1
    • 1
    ELISA
    交叉反应
    纯化方法
    >95%, Protein G purified
    免疫原
    Recombinant Human E3 ubiquitin-protein ligase RNF4 protein (1-103AA)
    亚型
    IgG
    Top Product
    Discover our top product RNF4 Primary Antibody
  • 应用备注
    Optimal working dilution should be determined by the investigator.
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4
    储存液
    ProClin
    注意事项
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C,-80 °C
    储存方法
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 抗原
    RNF4 (Ring Finger Protein 4 (RNF4))
    别名
    RNF4 (RNF4 产品)
    别名
    SLX5 antibody, SNURF antibody, AU018689 antibody, Gtrgeo8 antibody, ring finger protein 4 antibody, RNF4 antibody, Rnf4 antibody
    背景

    Background: E3 ubiquitin-protein ligase which binds polysumoylated chains covalently attached to proteins and mediates \'Lys-6\'-, \'Lys-11\'-, \'Lys-48\'- and \'Lys-63\'-linked polyubiquitination of those substrates and their subsequent targeting to the proteasome for degradation. Regulates the degradation of several proteins including PML and the transcriptional activator PEA3. Involved in chromosome alignment and spindle assembly, it regulates the kinetochore CENPH-CENPI-CENPK complex by targeting polysumoylated CENPI to proteasomal degradation. Regulates the cellular responses to hypoxia and heat shock through degradation of respectively EPAS1 and PARP1. Alternatively, it may also bind DNA/nucleosomes and have a more direct role in the regulation of transcription for instance enhancing basal transcription and steroid receptor-mediated transcriptional activation.

    Aliases: E3 ubiquitin ligase RNF4 antibody, E3 ubiquitin protein ligase RNF4 antibody, Protein SNURF antibody, RES4 26 antibody, RING finger protein 4 antibody, Rnf4 antibody, RNF4_HUMAN antibody, SLX5 antibody, Small nuclear ring finger protein antibody, SNURF antibody

    UniProt
    P78317
    途径
    Intracellular Steroid Hormone Receptor Signaling Pathway
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