DDB1 抗体 (AA 741-943)
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北京 101111
Quick Overview for DDB1 抗体 (AA 741-943) (ABIN7150124)
抗原
See all DDB1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 741-943
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原理
- DDB1 Antibody
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纯化方法
- Protein G purified
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纯度
- >95 %
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免疫原
- Recombinant Human DNA damage-binding protein 1 protein (741-943AA)
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亚型
- IgG
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anti-Damage Specific DNA Binding Protein 1 (DDB1) (C-Term) antibody
Verified DDB1 适用: 人, 小鼠 WB, IHC, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Damage Specific DNA Binding Protein 1 (DDB1) (C-Term) antibodyKO Validated DDB1 适用: 人 WB, IF, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Damage Specific DNA Binding Protein 1 (DDB1) (C-Term) antibodyDDB1 适用: 人 WB, IHC, IP 宿主: 兔 Polyclonal unconjugated
anti-Damage Specific DNA Binding Protein 1 (DDB1) antibodyDDB1 适用: 人 WB, IHC, IP 宿主: 兔 Monoclonal unconjugated
anti-Damage Specific DNA Binding Protein 1 (DDB1) antibodyDDB1 适用: 人, 小鼠, 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Damage Specific DNA Binding Protein 1 (DDB1) (AA 1011-1140) antibodyDDB1 适用: 人, 小鼠, 大鼠 WB, IHC, IF, ICC, IHC (fro), FACS 宿主: 兔 Polyclonal unconjugated
anti-Damage Specific DNA Binding Protein 1 (DDB1) (AA 1044-1140) antibodyDDB1 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 4C5 unconjugated
anti-Damage Specific DNA Binding Protein 1 (DDB1) (C-Term) antibodyDDB1 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Damage Specific DNA Binding Protein 1 (DDB1) antibodyKD Validated DDB1 适用: 人 WB, FACS 宿主: 兔 Monoclonal 23GB2265 unconjugated Recombinant Antibody
anti-Damage Specific DNA Binding Protein 1 (DDB1) antibodyDDB1 适用: 人 WB, IHC, ELISA, IP, IHC (p) 宿主: 小鼠 Monoclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 -
储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- DDB1 (Damage Specific DNA Binding Protein 1 (DDB1))
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别名
- DDB1
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背景
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Background: Required for DNA repair. Binds to DDB2 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches. Also appears to function as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the DCX E3 ubiquitin-protein ligase complex is determined by the variable substrate recognition component recruited by DDB1. DCX(DDB2) (also known as DDB1-CUL4-ROC1, CUL4-DDB-ROC1 and CUL4-DDB-RBX1) may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV-induced DNA damage. The ubiquitination of histones may facilitate their removal from the nucleosome and promote subsequent DNA repair. DCX(DDB2) also ubiquitinates XPC, which may enhance DNA-binding by XPC and promote NER. DCX(DTL) plays a role in PCNA-dependent polyubiquitination of CDT1 and MDM2-dependent ubiquitination of TP53 in response to radiation-induced DNA damage and during DNA replication. DCX(ERCC8) (the CSA complex) plays a role in transcription-coupled repair (TCR). May also play a role in ubiquitination of CDKN1B/p27kip when associated with CUL4 and SKP2.
Aliases: Damage specific DNA binding protein 1 antibody, Damage-specific DNA-binding protein 1 antibody, DDB 1 antibody, DDB p127 subunit antibody, Ddb1 antibody, DDB1_HUMAN antibody, DDBa antibody, DNA damage binding protein 1 antibody, DNA damage-binding protein 1 antibody, DNA damage-binding protein a antibody, HBV X-associated protein 1 antibody, UV damaged DNA binding factor antibody, UV damaged DNA binding protein 1 antibody, UV DDB 1 antibody, UV DDB1 antibody, UV-damaged DNA-binding factor antibody, UV-damaged DNA-binding protein 1 antibody, UV-DDB 1 antibody, X associated protein 1 antibody, XAP 1 antibody, XAP-1 antibody, XAP1 antibody, Xeroderma pigmentosum group E complementing protein antibody, Xeroderma pigmentosum group E-complementing protein antibody, XPCe antibody, XPE antibody, XPE BF antibody, XPE binding factor antibody, XPE-BF antibody, XPE-binding factor antibody
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UniProt
- Q16531
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途径
- DNA Damage Repair
抗原
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