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MAPKAP Kinase 5 抗体 (pThr182)

Name: MAPKAP Kinase 5 抗体 (pThr182)
SKU: ABIN710546
Availability: OutOfStock

This anti-MAPKAP Kinase 5 antibody is a 兔多克隆 antibody detecting MAPKAP Kinase 5 in WB, ELISA, IF (cc), IF (p), IHC (p) 和 IHC (fro). Suitable for 大鼠.

Formalin-fixed and paraffin embedded rat brain labeled with Anti-phospho-MAPKAPK5(Thr182) Polyclonal Antibody, Unconjugated (ABIN710546) at 1:200, followed by conjugation to the secondary antibody and DAB staining (MAPKAP Kinase 5 抗体 (pThr182))

IHC

Antigen: 0. (MAPKAP Kinase 5 抗体 (pThr182))

ELISA

Lane 1: mouse lung lysates Lane 2: mouse brain lysates probed with Anti phospho-MAPKAPK5(Thr182) Polyclonal Antibody, Unconjugated (ABIN710546) at 1:200 in 4 °C. (MAPKAP Kinase 5 抗体 (pThr182))

SDS

3 images

产品编号 ABIN710546

发货至: 中国

Quick Overview for MAPKAP Kinase 5 抗体 (pThr182) (ABIN710546)

抗原

See all MAPKAP Kinase 5 (MAPKAPK5) 抗体

MAPKAP Kinase 5 (MAPKAPK5) (Mitogen-Activated Protein Kinase-Activated Protein Kinase 5 (MAPKAPK5))

适用

大鼠

宿主

兔

克隆类型

多克隆

标记

This MAPKAP Kinase 5 antibody is un-conjugated

应用范围

Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

抗原表位
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pThr182

特异性

This phosphorylation site is homologous to that of Thr182 in Mouse.

交叉反应

大鼠

预测反应

Human,Mouse,Dog,Cow,Pig,Horse,Chicken,Rabbit

纯化方法

Purified by Protein A.

免疫原

KLH conjugated synthetic phosphopeptide derived from human MAPKAPK5 around the phosphorylation site of Thr182

亚型

IgG
anti-Mitogen-Activated Protein Kinase-Activated Protein Kinase 5 (MAPKAPK5) (AA 371-471) antibody
MAPKAPK5 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 3D7 unconjugated

anti-Mitogen-Activated Protein Kinase-Activated Protein Kinase 5 (MAPKAPK5) (pThr182) antibody
MAPKAPK5 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Mitogen-Activated Protein Kinase-Activated Protein Kinase 5 (MAPKAPK5) antibody
MAPKAPK5 适用: 人 ELISA, IHC 宿主: 小鼠 Monoclonal 7H10B4 unconjugated

anti-Mitogen-Activated Protein Kinase-Activated Protein Kinase 5 (MAPKAPK5) (pSer93) antibody
MAPKAPK5 适用: 人, 小鼠, 大鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Mitogen-Activated Protein Kinase-Activated Protein Kinase 5 (MAPKAPK5) (Internal Region) antibody
Verified MAPKAPK5 适用: 人, 小鼠 WB, ELISA, IHC, IP 宿主: 山羊 Polyclonal unconjugated

anti-Mitogen-Activated Protein Kinase-Activated Protein Kinase 5 (MAPKAPK5) (AA 1-471) antibody
MAPKAPK5 适用: 人 WB, PLA 宿主: 兔 Polyclonal unconjugated

anti-Mitogen-Activated Protein Kinase-Activated Protein Kinase 5 (MAPKAPK5) (AA 1-471) antibody
MAPKAPK5 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated

anti-Mitogen-Activated Protein Kinase-Activated Protein Kinase 5 (MAPKAPK5) (AA 371-471) antibody
MAPKAPK5 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2D5 unconjugated

anti-Mitogen-Activated Protein Kinase-Activated Protein Kinase 5 (MAPKAPK5) (AA 1-471) antibody
MAPKAPK5 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated

anti-Mitogen-Activated Protein Kinase-Activated Protein Kinase 5 (MAPKAPK5) antibody
MAPKAPK5 适用: 人 WB, IF, ICC 宿主: 兔 Polyclonal unconjugated

应用备注

WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

限制

仅限研究用
状态

Liquid

浓度

1 μg/μL

缓冲液

0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

储存液

ProClin

注意事项

This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

有效期

12 months
抗原

MAPKAP Kinase 5 (MAPKAPK5) (Mitogen-Activated Protein Kinase-Activated Protein Kinase 5 (MAPKAPK5))

别名

MAPKAPK5

背景

Synonyms: MK5, MK-5, PRAK, MAPKAP-K5, MAP kinase-activated protein kinase 5, MAPK-activated protein kinase 5, MAPKAP kinase 5, MAPKAPK-5, p38-regulated/activated protein kinase, MAPKAPK5
Background: Tumor suppressor serine/threonine-protein kinase involved in mTORC1 signaling and post-transcriptional regulation. Phosphorylates FOXO3, ERK3/MAPK6, ERK4/MAPK4, HSP27/HSPB1, p53/TP53 and RHEB. Acts as a tumor suppressor by mediating Ras-induced senescence and phosphorylating p53/TP53. Involved in post-transcriptional regulation of MYC by mediating phosphorylation of FOXO3: phosphorylation of FOXO3 leads to promote nuclear localization of FOXO3, enabling expression of miR-34b and miR-34C, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent MYC translation. Acts as a negative regulator of mTORC1 signaling by mediating phosphorylation and inhibition of RHEB. Part of the atypical MAPK signaling via its interaction with ERK3/MAPK6 or ERK4/MAPK4: the precise role of the complex formed with ERK3/MAPK6 or ERK4/MAPK4 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPK (ERK3/MAPK6 or ERK4/MAPK4), ERK3/MAPK6 (or ERK4/MAPK4) is phosphorylated and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6 (or ERK4/MAPK4). Mediates phosphorylation of HSP27/HSPB1 in response to PKA/PRKACA stimulation, inducing F-actin rearrangement.

基因ID

8550

UniProt

Q8IW41

途径

MAPK Pathway