UIMC1 抗体 (AA 161-235)
Quick Overview for UIMC1 抗体 (AA 161-235) (ABIN7145750)
抗原
See all UIMC1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 161-235
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交叉反应
- 人, 大鼠
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纯化方法
- >95%, Protein G purified
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免疫原
- Recombinant Human BRCA1-A complex subunit RAP80 protein (161-235AA)
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亚型
- IgG
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anti-Ubiquitin Interaction Motif Containing 1 (UIMC1) (AA 1-385) antibody
UIMC1 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Interaction Motif Containing 1 (UIMC1) (AA 1-230) antibodyUIMC1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Interaction Motif Containing 1 (UIMC1) (AA 567-601), (C-Term) antibodyUIMC1 适用: 人 WB, FACS 宿主: 兔 Polyclonal RB48354 unconjugated
anti-Ubiquitin Interaction Motif Containing 1 (UIMC1) (Internal Region) antibodyVerified UIMC1 适用: 人 ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
anti-Ubiquitin Interaction Motif Containing 1 (UIMC1) antibodyUIMC1 适用: 人, 小鼠, 大鼠 IF 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Interaction Motif Containing 1 (UIMC1) (AA 1-385) antibodyUIMC1 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Ubiquitin Interaction Motif Containing 1 (UIMC1) (N-Term) antibodyUIMC1 适用: 人, 小鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Interaction Motif Containing 1 (UIMC1) (C-Term) antibodyUIMC1 适用: 人, 小鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
- Recommended dilution: WB:1:500-1:5000, IHC:1:500-1:1000,
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 -
储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- UIMC1 (Ubiquitin Interaction Motif Containing 1 (UIMC1))
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别名
- UIMC1
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背景
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Background: Ubiquitin-binding protein (PubMed:24627472). Specifically recognizes and binds \\\'Lys-63\\\'-linked ubiquitin (PubMed:19328070, Ref.36). Plays a central role in the BRCA1-A complex by specifically binding \\\'Lys-63\\\'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes \\\'Lys-63\\\'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than \\\'Lys-63\\\'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B, the relevance of such results is however unclear in vivo. Does not bind Lys-48\\\'-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1.
Aliases: BRCA1-A complex subunit RAP80 antibody, Nuclear zinc finger protein RAP80 antibody, OTTHUMP00000161441 antibody, OTTHUMP00000223372 antibody, OTTHUMP00000223374 antibody, RAP80 antibody, Receptor associated protein 80 antibody, Receptor-associated protein 80 antibody, Retinoid X receptor interacting protein 110 antibody, Retinoid x receptor interacting protein antibody, Retinoid X receptor-interacting protein 110 antibody, RIP110 antibody, Rxrip110 antibody, Ubiquitin interaction motif containing 1 antibody, Ubiquitin interaction motif containing protein 1 antibody, Ubiquitin interaction motif-containing protein 1 antibody, UIMC1 antibody, UIMC1_HUMAN antibody, X2HRIP110 antibody
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UniProt
- Q96RL1
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途径
- DNA Damage Repair, Nuclear Hormone Receptor Binding, Positive Regulation of Response to DNA Damage Stimulus
抗原
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