NR1H4 抗体 (AA 1-476)
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北京 101111
Quick Overview for NR1H4 抗体 (AA 1-476) (ABIN7145584)
抗原
See all NR1H4 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-476
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原理
- NR1H4 Antibody
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纯化方法
- Protein G purified
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纯度
- >95 %
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免疫原
- Recombinant Human Bile acid receptor protein (1-476AA)
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亚型
- IgG
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 -
储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- NR1H4 (Nuclear Receptor Subfamily 1, Group H, Member 4 (NR1H4))
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别名
- NR1H4
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背景
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Background: Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two distinct mechanisms. Activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus.
Aliases: BAR antibody, Bile acid receptor antibody, Farnesoid X activated receptor antibody, Farnesoid X receptor antibody, Farnesoid X-activated receptor antibody, Farnesol receptor HRR 1 antibody, Farnesol receptor HRR-1 antibody, Farnesol receptor HRR1 antibody, FXR antibody, HRR 1 antibody, HRR1 antibody, NR1H4 antibody, NR1H4_HUMAN antibody, Nuclear receptor subfamily 1 group H member 4 antibody, Retinoid X receptor interacting protein 14 antibody, Retinoid X receptor-interacting protein 14 antibody, RIP 14 antibody, RIP14 antibody, RXR interacting protein 14 antibody, RXR-interacting protein 14 antibody
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UniProt
- Q96RI1
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途径
- Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Carbohydrate Metabolic Process
抗原
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