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NR1H4 抗体 (AA 175-280)

Name: NR1H4 抗体 (AA 175-280)
SKU: ABIN1714781
Availability: OutOfStock

There are 6+ publications for this product available. The 兔多克隆 anti-NR1H4 antibody is suitable to detect NR1H4 in samples from 人, 大鼠和小鼠. It has been validated for WB, ELISA, ICC, IF (cc), IF (p), IHC (p) 和 IHC (fro).

Lane 1: HepG2 lysates probed with Bile Acid Receptor NR1H4 Antibody at 1:300 overnight at 4˚C. (NR1H4 抗体 (AA 175-280))

SRT1720 restored the protein expressions of FXR, Bsep, and Mrp2 in mice total livers. (NR1H4 抗体 (AA 175-280))

2 images

(6 references)

产品编号 ABIN1714781

发货至: 中国

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Quick Overview for NR1H4 抗体 (AA 175-280) (ABIN1714781)

抗原

See all NR1H4 抗体

NR1H4 (Nuclear Receptor Subfamily 1, Group H, Member 4 (NR1H4))

适用

人, 大鼠, 小鼠

宿主

兔

克隆类型

多克隆

标记

This NR1H4 antibody is un-conjugated

应用范围

Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Discover our top product NR1H4 Primary Antibody

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AA 175-280

交叉反应

人, 小鼠

预测反应

Rat,Dog,Cow,Sheep,Pig,Horse

纯化方法

Purified by Protein A.

免疫原

KLH conjugated synthetic peptide derived from human Bile Acid Receptor NR1H4

亚型

IgG
anti-Nuclear Receptor Subfamily 1, Group H, Member 4 (NR1H4) (AA 375-568) antibody
NR1H4 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Nuclear Receptor Subfamily 1, Group H, Member 4 (NR1H4) (AA 363-472) antibody
NR1H4 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 1B10 unconjugated

anti-Nuclear Receptor Subfamily 1, Group H, Member 4 (NR1H4) (Middle Region) antibody
NR1H4 适用: 人, 大鼠, 小鼠, 犬, 马, Cow, 兔, 豚鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated

anti-Nuclear Receptor Subfamily 1, Group H, Member 4 (NR1H4) (AA 194-243) antibody
NR1H4 适用: 人, 大鼠, 小鼠, 犬, 马, Cow, Pig, 豚鼠, 猴, Bat WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Nuclear Receptor Subfamily 1, Group H, Member 4 (NR1H4) (AA 4-24), (Isoform 2) antibody
NR1H4 适用: 人 WB, ELISA, IHC, IF, FACS 宿主: 小鼠 Monoclonal 322-1-2-2 unconjugated

anti-Nuclear Receptor Subfamily 1, Group H, Member 4 (NR1H4) (AA 211-486) antibody
NR1H4 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Nuclear Receptor Subfamily 1, Group H, Member 4 (NR1H4) (AA 207-476) antibody
NR1H4 适用: 人 WB 宿主: 兔 Polyclonal unconjugated

anti-Nuclear Receptor Subfamily 1, Group H, Member 4 (NR1H4) (AA 1-476) antibody
NR1H4 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated

anti-Nuclear Receptor Subfamily 1, Group H, Member 4 (NR1H4) (Internal Region) antibody
Verified NR1H4 适用: 人 ELISA, IF, FACS 宿主: 山羊 Polyclonal unconjugated

anti-Nuclear Receptor Subfamily 1, Group H, Member 4 (NR1H4) (AA 323-372) antibody
NR1H4 适用: 人, 豚鼠, 猴 WB 宿主: 兔 Polyclonal unconjugated

应用备注

WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

限制

仅限研究用
状态

Liquid

浓度

1 μg/μL

缓冲液

0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

储存液

ProClin

注意事项

This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

有效期

12 months
Zhao, Elhafiz, Jiang, Das, Li, Zhou, Fan, Wang, Yuan, Xu, Jiang, Zhang, Wang: "Adaptive homeostasis of the vitamin D-vitamin D nuclear receptor axis in 8-methoxypsoralen-induced hepatotoxicity." in: Toxicology and applied pharmacology, Vol. 362, pp. 150-158, (2019) (PubMed).

Yang, Mei, Xu, Zhou, Zhu, Sun, Huang, Wang, Shu, Liu, Ding, Hassan, Zhang, Jiang: "Early indications of ANIT-induced cholestatic liver injury: Alteration of hepatocyte polarization and bile acid homeostasis." in: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, Vol. 110, pp. 1-12, (2018) (PubMed).

Zhang, Hwang, Oh, Park, Chung, Lee, Baek, Ryoo, Woo: "Effects of the fibrous topography-mediated macrophage phenotype transition on the recruitment of mesenchymal stem cells: An in vivo study." in: Biomaterials, Vol. 149, pp. 77-87, (2018) (PubMed).

Yu, Liu, Yuan, Li, Yang, Yuan, Sun, Zhang, Jiang: "SRT1720 Alleviates ANIT-Induced Cholestasis in a Mouse Model." in: Frontiers in pharmacology, Vol. 8, pp. 256, (2017) (PubMed).

Zhou, Lin, Chen, Wang, Liu, Xia: "Retinoic acid induces macrophage cholesterol efflux and inhibits atherosclerotic plaque formation in apoE-deficient mice." in: The British journal of nutrition, Vol. 114, Issue 4, pp. 509-18, (2015) (PubMed).
抗原

NR1H4 (Nuclear Receptor Subfamily 1, Group H, Member 4 (NR1H4))

别名

Bile Acid Receptor NR1H4

背景

Synonyms: BAR, FXR, HRR1, HRR-1, PFIC5, RIP14, Bile acid receptor, Farnesoid X-activated receptor, Farnesol receptor HRR-1, Nuclear receptor subfamily 1 group H member 4, Retinoid X receptor-interacting protein 14, RXR-interacting protein 14, NR1H4
Background: The steroid receptor superfamily acts through direct association with DNA sequences known as hormone response elements (HREs) and binds DNA as either homo- or heterodimers. The promiscuous mediator of heterodimerization, RXR, is the receptor for 9-cis retinoic acid, and dimerizes with VDR, TR, PPAR, and several novel receptors including LXR (also referred to as RLD-1) and FXR. FXR and LXR fall into a category of proteins termed orphan receptors? because of their lack of a defined function, and in the case of LXR, the lack of a defined ligand. FXR has been shown to bind a class of lipid molecules called farnesoids. LXR/RXR heterodimers have highest affinity for DR-4 DNA elements while FXR/RXR heterodimers bind IR-1 elements. Both LXR/RXR and FXR/RXR heterodimers retain their responsiveness to 9-cis retinoic acid.

基因ID

9971

UniProt

Q96RI1

途径

Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Carbohydrate Metabolic Process