BBS1 抗体 (AA 217-417)
Quick Overview for BBS1 抗体 (AA 217-417) (ABIN7145231)
抗原
See all BBS1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 217-417
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交叉反应
- 人, 小鼠
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纯化方法
- >95%, Protein G purified
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免疫原
- Recombinant Human Bardet-Biedl syndrome 1 protein (217-417AA)
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亚型
- IgG
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anti-Bardet-Biedl Syndrome 1 (BBS1) (AA 187-295) antibody
BBS1 适用: 人 ELISA, WB 宿主: 小鼠 Polyclonal unconjugated
anti-Bardet-Biedl Syndrome 1 (BBS1) (AA 435-552) antibodyBBS1 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Bardet-Biedl Syndrome 1 (BBS1) (AA 110-159) antibodyBBS1 适用: 人, 小鼠, 大鼠, 马 WB 宿主: 兔 Polyclonal unconjugated
anti-Bardet-Biedl Syndrome 1 (BBS1) (N-Term) antibodyBBS1 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Bardet-Biedl Syndrome 1 (BBS1) (N-Term) antibodyBBS1 适用: 人, 小鼠, 大鼠, 马, Cow, 犬, 豚鼠, Pig WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200,
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 -
储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- BBS1 (Bardet-Biedl Syndrome 1 (BBS1))
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别名
- BBS1
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背景
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Background: The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for proper BBSome complex assembly and its ciliary localization.
Aliases: AI451249 antibody, Bardet-Biedl syndrome 1 antibody, Bardet-Biedl syndrome 1 homolog antibody, Bardet-Biedl syndrome 1 protein antibody, BBS1 antibody, BBS1_HUMAN antibody, BBS2-like protein 2 antibody, BBS2L2 antibody, D19Ertd609e antibody
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UniProt
- Q8NFJ9
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途径
- Hedgehog Signaling
抗原
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