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PDK4 抗体 (AA 143-333)

This anti-PDK4 antibody is a 兔 多克隆 antibody detecting PDK4 in IHC 和 ELISA. Suitable for 人.
产品编号 ABIN7142008
发货至: 中国

Quick Overview for PDK4 抗体 (AA 143-333) (ABIN7142008)

抗原

See all PDK4 抗体
PDK4 (Pyruvate Dehydrogenase Kinase, Isozyme 4 (PDK4))

适用

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宿主

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克隆类型

  • 75
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多克隆

标记

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This PDK4 antibody is un-conjugated

应用范围

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Immunohistochemistry (IHC), ELISA
  • 抗原表位

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    AA 143-333

    交叉反应

    纯化方法

    >95%, Protein G purified

    免疫原

    Recombinant Human [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial protein (143-333AA)

    亚型

    IgG
  • 应用备注

    Recommended dilution: IHC:1:20-1:200,

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

    储存液

    ProClin

    注意事项

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C,-80 °C

    储存方法

    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 抗原

    PDK4 (Pyruvate Dehydrogenase Kinase, Isozyme 4 (PDK4))

    别名

    PDK4

    背景

    Background: Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Inhibition of pyruvate dehydrogenase decreases glucose utilization and increases fat metabolism in response to prolonged fasting and starvation. Plays an important role in maintaining normal blood glucose levels under starvation, and is involved in the insulin signaling cascade. Via its regulation of pyruvate dehydrogenase activity, plays an important role in maintaining normal blood pH and in preventing the accumulation of ketone bodies under starvation. In the fed state, mediates cellular responses to glucose levels and to a high-fat diet. Regulates both fatty acid oxidation and de novo fatty acid biosynthesis. Plays a role in the generation of reactive oxygen species. Protects detached epithelial cells against anoikis. Plays a role in cell proliferation via its role in regulating carbohydrate and fatty acid metabolism.

    Aliases: [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 4 antibody, FLJ40832 antibody, mitochondrial antibody, Pdk4 antibody, PDK4_HUMAN antibody, Pyruvate dehydrogenase [lipoamide] kinase isozyme 4 mitochondrial antibody, Pyruvate dehydrogenase kinase 4 antibody, Pyruvate dehydrogenase kinase isoenzyme 4 antibody, Pyruvate dehydrogenase kinase isoform 4 antibody, Pyruvate dehydrogenase kinase isozyme 4 antibody, Pyruvate dehydrogenase kinase isozyme 4 mitochondrial antibody

    UniProt

    Q16654

    途径

    PI3K-Akt Signaling, Hedgehog Signaling, Carbohydrate Homeostasis, Regulation of Carbohydrate Metabolic Process, Warburg Effect
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