UBC 抗体 (AA 19-36) (HRP)
Quick Overview for UBC 抗体 (AA 19-36) (HRP) (ABIN7140063)
抗原
See all UBC 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 19-36
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交叉反应
- 人
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纯化方法
- Antigen Affinity Purified
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免疫原
- Peptide sequence from Human Polyubiquitin-C protein (19-36AA)
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亚型
- IgG
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anti-Ubiquitin C (UBC) (AA 1-100) antibody
UBC 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin C (UBC) (AA 36-66) antibodyUBC 适用: 人 WB, IHC, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin C (UBC) (AA 1-32) antibodyUBC 适用: 人 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin C (UBC) (AA 19-36) antibodyUBC 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin C (UBC) (C-Term) antibodyUBC 适用: 人 WB, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin C (UBC) (N-Term) antibodyUBC 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 -
储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- UBC (Ubiquitin C (UBC))
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别名
- UBC
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背景
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Background: Ubiquitin: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair, Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation, Lys-29-linked is involved in lysosomal degradation, Lys-33-linked is involved in kinase modification, Lys-48-linked is involved in protein degradation via the proteasome, Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling.
Aliases: UBC antibody, Polyubiquitin-C [Cleaved into: Ubiquitin] antibody
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UniProt
- P0CG48
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途径
- Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Mitotic G1-G1/S Phases, DNA Replication, Toll-Like Receptors Cascades, Synthesis of DNA, EGFR Downregulation, Ubiquitin Proteasome Pathway
抗原
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