MUSK 抗体 (pTyr755)
Quick Overview for MUSK 抗体 (pTyr755) (ABIN7139062)
抗原
See all MUSK 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- pTyr755
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交叉反应
- 人, 小鼠, 大鼠
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纯化方法
- Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
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免疫原
- Peptide sequence around phosphorylation site of tyrosine 755(A-D-Y(p)-Y-K) derived from Human MuSK .
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亚型
- IgG
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anti-Muscle, Skeletal, Receptor Tyrosine Kinase (MUSK) (AA 517-777) antibody
MUSK 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Muscle, Skeletal, Receptor Tyrosine Kinase (MUSK) (AA 35-65), (N-Term) antibodyMUSK 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB01497 unconjugated
anti-Muscle, Skeletal, Receptor Tyrosine Kinase (MUSK) (AA 35-65) antibodyMUSK 适用: 人 WB, ELISA, IHC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Muscle, Skeletal, Receptor Tyrosine Kinase (MUSK) (AA 301-400) antibodyMUSK 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 2H6 unconjugated
anti-Muscle, Skeletal, Receptor Tyrosine Kinase (MUSK) antibodyMUSK 适用: 人, 小鼠 WB, ELISA, FACS, IF 宿主: 兔 Polyclonal unconjugated
anti-Muscle, Skeletal, Receptor Tyrosine Kinase (MUSK) (AA 829-859) antibodyMUSK 适用: 人 WB, ELISA, IHC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Muscle, Skeletal, Receptor Tyrosine Kinase (MUSK) antibodyMUSK 适用: 人, 小鼠 WB, FACS, IF 宿主: 兔 Polyclonal RB14743 unconjugated
anti-Muscle, Skeletal, Receptor Tyrosine Kinase (MUSK) (AA 301-400) antibodyMUSK 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1F3 unconjugated
anti-Muscle, Skeletal, Receptor Tyrosine Kinase (MUSK) (AA 24-209) antibodyMUSK 适用: 人 ELISA, IHC, ICC 宿主: 小鼠 Monoclonal 10A4 unconjugated
anti-Muscle, Skeletal, Receptor Tyrosine Kinase (MUSK) antibodyMUSK 适用: 小鼠, 大鼠 WB, IHC (p) 宿主: 小鼠 Monoclonal 6D1 unconjugated
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应用备注
- WB:1:500-1:1000,
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- MUSK (Muscle, Skeletal, Receptor Tyrosine Kinase (MUSK))
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别名
- MUSK
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背景
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Background:
Receptor tyrosine kinase which plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between the motor neuron and the skeletal muscle. Recruitment of AGRIN by LRP4 to the MUSK signaling complex induces phosphorylation and activation of MUSK, the kinase of the complex. The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, the reorganization of the actin cytoskeleton and the clustering of the acetylcholine receptors (AChR) in the postsynaptic membrane.
Valenzuela D.M., Neuron 15:573-584(1995).
Humphray S.J., Nature 429:369-374(2004).
Bergamin E., Mol. Cell 39:100-109(2010).Aliases: CMS9 antibody, FADS antibody, MDK 4 antibody, MDK4 antibody, MGC126323 antibody, MGC126324 antibody, Muscle antibody, Muscle associated receptor tyrosine kinase antibody, Muscle skeletal receptor tyrosine kinase antibody, Muscle skeletal receptor tyrosine protein kinase antibody, Muscle specific kinase receptor antibody, Muscle specific tyrosine kinase receptor antibody, Muscle specific tyrosine protein kinase receptor antibody, Muscle-specific kinase receptor antibody, Muscle-specific tyrosine-protein kinase receptor antibody, MuSK antibody, MUSK_HUMAN antibody, Neural fold somite kinase 1 antibody, Neural fold somite kinase 2 antibody, Neural fold somite kinase 3 antibody, Neural fold somite kinase1 antibody, Neural fold somite kinase2 antibody, Neural fold somite kinase3 antibody, Nsk 1 antibody, Nsk 2 antibody, Nsk 3 antibody, Nsk1 antibody, Nsk2 antibody, Nsk3 antibody, Receptor tyrosine kinase MuSK antibody, Skeletal muscle receptor tyrosine kinase antibody, skeletal receptor tyrosine-protein kinase antibody
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UniProt
- O15146
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途径
- RTK signaling, Regulation of Muscle Cell Differentiation, Synaptic Membrane, Regulation of Cell Size, Skeletal Muscle Fiber Development
抗原
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