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HNRNPK 抗体 (pSer216)

This anti-HNRNPK antibody is a 兔 多克隆 antibody detecting HNRNPK in WB 和 ELISA. Suitable for 人.
产品编号 ABIN7138482
发货至: 中国

Quick Overview for HNRNPK 抗体 (pSer216) (ABIN7138482)

抗原

See all HNRNPK 抗体
HNRNPK (Heterogeneous Nuclear Ribonucleoprotein K (HNRNPK))

适用

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宿主

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克隆类型

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多克隆

标记

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This HNRNPK antibody is un-conjugated

应用范围

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Western Blotting (WB), ELISA
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    pSer216

    交叉反应

    人, 小鼠, 大鼠

    纯化方法

    Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

    免疫原

    Peptide sequence around phosphorylation site of serine 216 (S-E-S(p)-P-I) derived from Human hnRNP K.

    亚型

    IgG
  • 应用备注

    WB:1:500-1:3000,

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C,-80 °C

    储存方法

    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 抗原

    HNRNPK (Heterogeneous Nuclear Ribonucleoprotein K (HNRNPK))

    别名

    HNRNPK

    背景

    Background: One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction By similarity. As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest.

    Aliases: CSBP antibody, dC stretch binding protein antibody, FLJ41122 antibody, Heterogeneous nuclear ribonucleoprotein K antibody, hnRNP K antibody, HNRNPK antibody, HNRPK antibody, HNRPK_HUMAN antibody, Transformation up regulated nuclear protein antibody, Transformation up-regulated nuclear protein antibody, Transformation upregulated nuclear protein antibody, TUNP antibody

    UniProt

    P61978
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