CDK2 抗体 (pThr14)
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北京 101111
Quick Overview for CDK2 抗体 (pThr14) (ABIN7138398)
抗原
See all CDK2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- pThr14
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原理
- Phospho-CDK2 (Thr14) Antibody
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交叉反应
- 小鼠, 大鼠
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纯化方法
- Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
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免疫原
- Peptide sequence around phospho rylation site of threonine14(E-G-T(p)-Y-G) derived from Human CDK1/CDC2 .
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亚型
- IgG
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anti-Cyclin-Dependent Kinase 2 (CDK2) antibody
CDK2 适用: 人, 小鼠 WB, IHC, ELISA, ICC, FACS 宿主: 小鼠 Monoclonal 1A6 unconjugated
anti-Cyclin-Dependent Kinase 2 (CDK2) (AA 197-295) antibodyCDK2 适用: 人, 小鼠 WB, IHC, ELISA, IF, FACS 宿主: 小鼠 Monoclonal 1A6 unconjugated
anti-Cyclin-Dependent Kinase 2 (CDK2) (AA 211-298) antibodyCDK2 适用: 人 WB, ELISA, RNAi 宿主: 小鼠 Monoclonal 2E8 unconjugated
anti-Cyclin-Dependent Kinase 2 (CDK2) antibodyCDK2 适用: 人, 猴 WB, IF, FACS 宿主: 小鼠 Monoclonal 4B4 unconjugated
anti-Cyclin-Dependent Kinase 2 (CDK2) (AA 1-298) antibodyCDK2 适用: 人 WB, IHC, ELISA, IP, IF 宿主: 兔 Polyclonal unconjugated
anti-Cyclin-Dependent Kinase 2 (CDK2) antibodyKD Validated CDK2 适用: 人 WB, FACS, IF (p) 宿主: 兔 Monoclonal 23GB2295 unconjugated Recombinant Antibody
anti-Cyclin-Dependent Kinase 2 (CDK2) antibodyKD Validated CDK2 适用: 人 WB, FACS, IF (p) 宿主: 兔 Monoclonal 24GB4315 unconjugated Recombinant Antibody
anti-Cyclin-Dependent Kinase 2 (CDK2) antibodyCDK2 适用: 人, 猴 WB, IF, FACS 宿主: 小鼠 Monoclonal 1C4 unconjugated
anti-Cyclin-Dependent Kinase 2 (CDK2) (AA 81-298) antibodyCDK2 适用: 人 WB, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Cyclin-Dependent Kinase 2 (CDK2) (AA 94-198) antibodyCDK2 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- CDK2 (Cyclin-Dependent Kinase 2 (CDK2))
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别名
- CDK2
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背景
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Background:
Serine/threonine-protein kinase involved in the control of the cell cycle, essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Interacts with cyclins A, B1, B3, D, or E. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression, controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK1 at the centrosome and in the nucleus.
Sarkar S, Dey BK, Dutta A (2010) Mol Biol Cell 21, 2138-49
Shreeram S, Hee WK, Bulavin DV (2008) Mol Cell Biol 28, 7442-50
Mayya V, et al. (2006) Mol Cell Proteomics 5, 1146-57Aliases: Cdc2 related protein kinase antibody, cdc2-related protein kinase antibody, CDC28 antibody, CDC2A antibody, Cdk 2 antibody, CDK1 antibody, CDK2 antibody, CDK2_HUMAN antibody, CDKN2 antibody, Cell devision kinase 2 antibody, Cell division protein kinase 2 antibody, Cyclin dependent kinase 2 antibody, cyclin dependent kinase 2-alpha antibody, Cyclin-dependent kinase 2 antibody, kinase Cdc2 antibody, MPF antibody, p33 protein kinase antibody, p33(CDK2) antibody
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UniProt
- P24941
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途径
- PI3K-Akt Signaling, Cell Division Cycle, Mitotic G1-G1/S Phases, DNA Replication, M Phase, Synthesis of DNA
抗原
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