WWTR1 抗体
Quick Overview for WWTR1 抗体 (ABIN7138224)
抗原
See all WWTR1 抗体适用
宿主
克隆类型
标记
应用范围
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交叉反应
- 人, 小鼠, 大鼠
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纯化方法
- Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
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免疫原
- Peptide sequence around aa.386~390 (V-E-S-A-L) derived from Human TAZ.
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亚型
- IgG
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anti-WW Domain Containing Transcription Regulator 1 (WWTR1) (AA 1-230) antibody
WWTR1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-WW Domain Containing Transcription Regulator 1 (WWTR1) (N-Term) antibodyWWTR1 适用: 人, 小鼠, 大鼠, 犬, Cow, 豚鼠, 兔 WB 宿主: 兔 Polyclonal unconjugated
anti-WW Domain Containing Transcription Regulator 1 (WWTR1) (AA 201-300) antibodyWWTR1 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 1F1 unconjugated
anti-WW Domain Containing Transcription Regulator 1 (WWTR1) (C-Term) antibodyWWTR1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-WW Domain Containing Transcription Regulator 1 (WWTR1) antibodyWWTR1 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-WW Domain Containing Transcription Regulator 1 (WWTR1) (AA 296-330), (C-Term) antibodyWWTR1 适用: 人 WB 宿主: 兔 Polyclonal RB51589 unconjugated
anti-WW Domain Containing Transcription Regulator 1 (WWTR1) (AA 296-330), (C-Term) antibodyWWTR1 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB51590 unconjugated
anti-WW Domain Containing Transcription Regulator 1 (WWTR1) (C-Term) antibodyWWTR1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-WW Domain Containing Transcription Regulator 1 (WWTR1) antibodyWWTR1 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB:1:500-1:1000,
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Supplied at 1.0 mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- WWTR1 (WW Domain Containing Transcription Regulator 1 (WWTR1))
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别名
- WWTR1
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背景
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Background: Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. Regulates the nuclear accumulation of SMADS and has a key role in coupling them to the transcriptional machinery such as the mediator complex. Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition.
Kanai F., Marignani P.A., Sarbassova D., Yagi R. EMBO J. 19:6778-6791(2000)
Lei Q.Y., Zhang H., Zhao B., Zha Z.Y. Mol. Cell. Biol. 28:2426-2436(2008)
Varelas X., Sakuma R., Samavarchi-Tehrani P., Peerani R. Nat. Cell Biol. 10:837-848(2008)
Di Palma T., D'Andrea B., Liguori G.L., Liguoro A. Exp. Cell Res. 315:162-175(2009)Aliases: DKFZP586I1419 antibody, FLJ27004 antibody, FLJ45718 antibody, OTTHUMP00000215994 antibody, OTTHUMP00000215995 antibody, OTTHUMP00000215996 antibody, OTTHUMP00000216001 antibody, TAZ antibody, Transcriptional co activator with PDZ binding motif antibody, Transcriptional coactivator with PDZ binding motif antibody, Transcriptional coactivator with PDZ-binding motif antibody, WW domain containing transcription regulator 1 antibody, WW domain containing transcription regulator protein 1 antibody, WW domain-containing transcription regulator protein 1 antibody, WWTR 1 antibody, WWTR1 antibody, WWTR1_HUMAN antibody
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UniProt
- Q9GZV5
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途径
- Regulation of Lipid Metabolism by PPARalpha
抗原
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