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Recombinant SUMO1 抗体

This anti-SUMO1 antibody is a 兔 单克隆 antibody detecting SUMO1 in IHC, ELISA, FACS 和 IP. Suitable for 人.
产品编号 ABIN7127830
发货至: 中国

Quick Overview for Recombinant SUMO1 抗体 (ABIN7127830)

抗原

See all SUMO1 抗体
SUMO1 (Small Ubiquitin Related Modifier Protein 1 (SUMO1))

抗体类型

Recombinant Antibody

适用

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宿主

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克隆类型

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单克隆

标记

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This SUMO1 antibody is un-conjugated

应用范围

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Immunohistochemistry (IHC), ELISA, Flow Cytometry (FACS), Immunoprecipitation (IP)

克隆位点

5G3
  • 交叉反应

    纯化方法

    Affinity-chromatography

    免疫原

    A synthesized peptide derived from human SUMO1

    亚型

    IgG
  • 应用备注

    Recommended dilution: IHC:1:50-1:200, IP:1:200-1:1000,

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C,-80 °C

    储存方法

    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 抗原

    SUMO1 (Small Ubiquitin Related Modifier Protein 1 (SUMO1))

    别名

    SUMO1

    背景

    Background: Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for instance in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Covalently attached to the voltage-gated potassium channel KCNB1, this modulates the gating characteristics of KCNB1 (PubMed:19223394). Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. May also regulate a network of genes involved in palate development. Covalently attached to ZFHX3 (PubMed:24651376).

    Aliases: Small ubiquitin-related modifier 1, SUMO-1, GAP-modifying protein 1, GMP1, SMT3 homolog 3, Sentrin, Ubiquitin-homology domain protein PIC1, Ubiquitin-like protein SMT3C, Smt3C, Ubiquitin-like protein UBL1, SUMO1, SMT3C, SMT3H3, UBL1, OK/SW-cl.43

    UniProt

    P63165

    途径

    M Phase, Positive Regulation of Endopeptidase Activity, Protein targeting to Nucleus, Ubiquitin Proteasome Pathway
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