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Recombinant MSK1 抗体 (pSer376)

Name: Recombinant MSK1 抗体 (pSer376)
Brand: antibodies-online
SKU: ABIN7127745
Availability: OutOfStock

This anti-MSK1 antibody is a 兔单克隆 antibody detecting MSK1 in ELISA 和 IHC. Suitable for 人.

IHC image of ABIN7127745 diluted at 1:100 and staining in paraffin-embedded human bladder cancer performed on a Leica BondTM system. (Recombinant MSK1 抗体 (pSer376))

IHC

1 image

产品编号 ABIN7127745

发货至: 中国

Datasheet as PDF

Quick Overview for Recombinant MSK1 抗体 (pSer376) (ABIN7127745)

抗原

See all MSK1 (RPS6KA5) 抗体

MSK1 (RPS6KA5) (Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 5 (RPS6KA5))

抗体类型

Recombinant Antibody

适用

人

宿主

兔

克隆类型

单克隆

标记

This MSK1 antibody is un-conjugated

应用范围

ELISA, Immunohistochemistry (IHC)

克隆位点

2F3

Discover our top product RPS6KA5 Primary Antibody

抗原表位
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1
pSer376

交叉反应

人

纯化方法

Affinity-chromatography

免疫原

A synthesized peptide derived from human Phospho-RPS6KA5 (S376)

亚型

IgG
anti-Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 5 (RPS6KA5) (AA 224-367) antibody
RPS6KA5 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 5 (RPS6KA5) (AA 271-370) antibody
RPS6KA5 适用: 人 WB, ELISA, IF, PLA 宿主: 小鼠 Monoclonal 2B11 unconjugated

anti-Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 5 (RPS6KA5) (pSer376) antibody
RPS6KA5 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated

anti-Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 5 (RPS6KA5) (AA 540-665) antibody
RPS6KA5 适用: 人, 小鼠, 大鼠 WB, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 5 (RPS6KA5) antibody
RPS6KA5 适用: 人 ELISA, IHC, IHC (p) 宿主: 小鼠 Monoclonal 1G7 unconjugated

anti-Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 5 (RPS6KA5) (AA 1-802) antibody
RPS6KA5 适用: 人 WB, PLA 宿主: 兔 Polyclonal unconjugated

anti-Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 5 (RPS6KA5) (Ser212) antibody
RPS6KA5 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated

anti-Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 5 (RPS6KA5) (Internal Region) antibody
RPS6KA5 适用: 人, 小鼠 WB, IF, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated

anti-Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 5 (RPS6KA5) (pSer212) antibody
RPS6KA5 适用: 大鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 5 (RPS6KA5) (pSer360) antibody
RPS6KA5 适用: 小鼠, 大鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

应用备注

Recommended dilution: IHC:1:50-1:200,

限制

仅限研究用
状态

Liquid

缓冲液

Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

-20 °C,-80 °C

储存方法

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
抗原

MSK1 (RPS6KA5) (Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 5 (RPS6KA5))

别名

RPS6KA5

背景

Background: Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factors RELA, STAT3 and ETV1/ER81, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes (PubMed:11909979, PubMed:12569367, PubMed:12763138, PubMed:9687510, PubMed:18511904, PubMed:9873047). Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin (PubMed:11909979, PubMed:9873047). Plays an essential role in the control of RELA transcriptional activity in response to TNF and upon glucocorticoid, associates in the cytoplasm with the glucocorticoid receptor NR3C1 and contributes to RELA inhibition and repression of inflammatory gene expression (PubMed:12628924, PubMed:18511904). In skeletal myoblasts is required for phosphorylation of RELA at 'Ser-276' during oxidative stress (PubMed:12628924). In erythropoietin-stimulated cells, is necessary for the 'Ser-727' phosphorylation of STAT3 and regulation of its transcriptional potential (PubMed:12763138). Phosphorylates ETV1/ER81 at 'Ser-191' and 'Ser-216', and thereby regulates its ability to stimulate transcription, which may be important during development and breast tumor formation (PubMed:12569367). Directly represses transcription via phosphorylation of 'Ser-1' of histone H2A (PubMed:15010469). Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN (PubMed:12773393). May also phosphorylate 'Ser-28' of histone H3 (PubMed:12773393). Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14) (PubMed:12773393). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines (By similarity). Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors (By similarity). Plays a role in neuronal cell death by mediating the downstream effects of excitotoxic injury (By similarity). Phosphorylates TRIM7 at 'Ser-107' in response to growth factor signaling via the MEK/ERK pathway, thereby stimulating its ubiquitin ligase activity (PubMed:25851810).
Aliases: Ribosomal protein S6 kinase alpha-5, S6K-alpha-5, 90 kDa ribosomal protein S6 kinase 5, Nuclear mitogen- and stress-activated protein kinase 1, RSK-like protein kinase, RSKL, RPS6KA5, MSK1

UniProt

O75582

途径

MAPK Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades