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Recombinant FAK 抗体 (pTyr397)

Name: Recombinant FAK 抗体 (pTyr397)
Brand: antibodies-online
SKU: ABIN7127734
Availability: OutOfStock

This anti-FAK antibody is a 兔单克隆 antibody detecting FAK in WB 和 ELISA. Suitable for 人.

Western Blot Positive WB detected in Hela whole cell lysate All lanes Phospho-PTK2 antibody at 3. (Recombinant FAK 抗体 (pTyr397))

1 image

产品编号 ABIN7127734

发货至: 中国

Datasheet as PDF

Quick Overview for Recombinant FAK 抗体 (pTyr397) (ABIN7127734)

抗原

See all FAK (PTK2) 抗体

FAK (PTK2) (PTK2 Protein tyrosine Kinase 2 (PTK2))

抗体类型

Recombinant Antibody

适用

人

宿主

兔

克隆类型

单克隆

标记

This FAK antibody is un-conjugated

应用范围

Western Blotting (WB), ELISA

克隆位点

1B3

Discover our top product PTK2 Primary Antibody

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pTyr397

交叉反应

人

纯化方法

Affinity-chromatography

免疫原

A synthesized peptide derived from human Phospho-PTK2 (Y397)

亚型

IgG
anti-PTK2 Protein tyrosine Kinase 2 (PTK2) (pTyr397) antibody
PTK2 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-PTK2 Protein tyrosine Kinase 2 (PTK2) (AA 700-800) antibody
PTK2 适用: 人 WB, IHC, IF, IP 宿主: 兔 Polyclonal unconjugated

anti-PTK2 Protein tyrosine Kinase 2 (PTK2) (AA 798-1041) antibody
PTK2 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated

anti-PTK2 Protein tyrosine Kinase 2 (PTK2) (AA 355-490) antibody
PTK2 适用: 人 WB, ELISA, IP, PLA 宿主: 小鼠 Monoclonal 2C3 unconjugated

anti-PTK2 Protein tyrosine Kinase 2 (PTK2) (pTyr576) antibody
PTK2 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-PTK2 Protein tyrosine Kinase 2 (PTK2) (AA 396-423) antibody
PTK2 适用: 人 WB, IF, FACS, IHC (p) 宿主: 兔 Polyclonal RB20775 unconjugated

anti-PTK2 Protein tyrosine Kinase 2 (PTK2) (C-Term) antibody
PTK2 适用: 人 WB, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated

anti-PTK2 Protein tyrosine Kinase 2 (PTK2) (AA 1-680) antibody
PTK2 适用: 人 WB, PLA 宿主: 兔 Polyclonal unconjugated

anti-PTK2 Protein tyrosine Kinase 2 (PTK2) (pTyr861) antibody
PTK2 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-PTK2 Protein tyrosine Kinase 2 (PTK2) antibody
PTK2 适用: 人 ELISA, FACS, ICC 宿主: 小鼠 Monoclonal 10H7E9 unconjugated

应用备注

Recommended dilution: WB:1:500-1:5000,

限制

仅限研究用
状态

Liquid

缓冲液

Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

-20 °C,-80 °C

储存方法

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
抗原

FAK (PTK2) (PTK2 Protein tyrosine Kinase 2 (PTK2))

别名

PTK2

背景

Background: Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. Required for early embryonic development and placenta development. Required for embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and normal heart development. Regulates axon growth and neuronal cell migration, axon branching and synapse formation, required for normal development of the nervous system. Plays a role in osteogenesis and differentiation of osteoblasts. Functions in integrin signal transduction, but also in signaling downstream of numerous growth factor receptors, G-protein coupled receptors (GPCR), EPHA2, netrin receptors and LDL receptors. Forms multisubunit signaling complexes with SRC and SRC family members upon activation, this leads to the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascade. Promotes activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling cascade. Promotes localized and transient activation of guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs), and thereby modulates the activity of Rho family GTPases. Signaling via CAS family members mediates activation of RAC1. Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, and thereby regulates P53/TP53 activity, P53/TP53 ubiquitination and proteasomal degradation. Phosphorylates SRC, this increases SRC kinase activity. Phosphorylates ACTN1, ARHGEF7, GRB7, RET and WASL. Promotes phosphorylation of PXN and STAT1, most likely PXN and STAT1 are phosphorylated by a SRC family kinase that is recruited to autophosphorylated PTK2/FAK1, rather than by PTK2/FAK1 itself. Promotes phosphorylation of BCAR1, GIT2 and SHC1, this requires both SRC and PTK2/FAK1. Promotes phosphorylation of BMX and PIK3R1. Isoform 6 (FRNK) does not contain a kinase domain and inhibits PTK2/FAK1 phosphorylation and signaling. Its enhanced expression can attenuate the nuclear accumulation of LPXN and limit its ability to enhance serum response factor (SRF)-dependent gene transcription.
Aliases: Focal adhesion kinase 1, FADK 1, Focal adhesion kinase-related nonkinase, FRNK, Protein phosphatase 1 regulatory subunit 71, PPP1R71, Protein-tyrosine kinase 2, p125FAK, pp125FAK, PTK2, FAK, FAK1

UniProt

Q05397

途径

Response to Growth Hormone Stimulus, CXCR4-mediated Signaling Events, Smooth Muscle Cell Migration, Signaling of Hepatocyte Growth Factor Receptor, VEGF Signaling