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Recombinant ADAM17 抗体

This anti-ADAM17 antibody is a 兔 单克隆 antibody detecting ADAM17 in ELISA 和 IF. Suitable for 人.
产品编号 ABIN7127323
发货至: 中国
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中国
北京 101111
No. 88 KeChuang 6th Street
Beijing Economic Technological Development Area
Room 801-803
4A Biotech Co.,Ltd.
Tel +86 (0512) 65829739 传真 +86 (010) 6788 5057

Quick Overview for Recombinant ADAM17 抗体 (ABIN7127323)

抗原

See all ADAM17 抗体
ADAM17 (ADAM Metallopeptidase Domain 17 (ADAM17))

抗体类型

Recombinant Antibody

适用

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宿主

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克隆类型

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单克隆

标记

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This ADAM17 antibody is un-conjugated

应用范围

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ELISA, Immunofluorescence (IF)

克隆位点

5A1
  • 原理

    ADAM17 Recombinant Monoclonal Antibody

    纯化方法

    Affinity-chromatography

    免疫原

    A synthesized peptide derived from human ADAM17

    亚型

    IgG
  • 应用备注

    IF:1:20-1:200

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C,-80 °C

    储存方法

    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 抗原

    ADAM17 (ADAM Metallopeptidase Domain 17 (ADAM17))

    别名

    ADAM17

    背景

    Background: Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT). Plays a role in the proteolytic processing of ACE2.

    Aliases: Disintegrin and metalloproteinase domain-containing protein 17 (ADAM 17) (EC 3.4.24.86) (Snake venom-like protease) (TNF-alpha convertase) (TNF-alpha-converting enzyme) (CD antigen CD156b), ADAM17, CSVP TACE

    UniProt

    P78536

    途径

    Notch Signaling, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Response to Growth Hormone Stimulus
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