Recombinant TIA1 抗体
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- 抗原 See all TIA1 抗体
- TIA1 (TIA1 Cytotoxic Granule-Associated RNA Binding Protein (TIA1))
- 抗体类型
- Recombinant Antibody
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适用
- 人
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宿主
- 兔
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克隆类型
- 单克隆
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标记
- This TIA1 antibody is un-conjugated
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应用范围
- Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
- 特异性
- The T cell intracellular antigen 1 (TIA 1) is a 17 kDa cytoplasmic granule associated protein also designated as GMP 17, for granule membrane protein of 17 kDa. The GMP 17/TIA 1 Molecule is expressed in cells possessing cytolytic potential and could be involved in the signaling cascade of Fas (CD95) mediated apoptosis. Within hematopoietic cell lines, the TIA1/1352R monoclonal antibody reacts with about 90 % of CD16+, 50 60 % of CD8+, and less than 10 % of CD4+ normal peripheral blood lymphocytes. It reacts with almost all monocytes and granulocytes. This antibody also reacts with CD4+ activated T cell clones, activated NK cell clones, and Con activated thymocytes, but not with B lymphocytes or B cell lines. TIA1 antibody labels cytotoxic T cells and natural killer cells (NK cells). It is also expressed in T-cell lymphoma, large granular lymphocyte (LGL) leukemia and hairy cell leukemia. TIA1 expression in T-cell malignancies may help in differentiating LGL leukemia (high expression) from T-cell lymphocytosis and other T-cell diseases (low expression). TIA1 may also be used to label tumor-infiltrating lymphocytes in the study of immune response to malignancies.
- 交叉反应 (详细)
- Human.
- 纯化方法
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
- 免疫原
- Human bone marrow malignant cells from a non B, non T acute leukemia
- 亚型
- IgG
- Top Product
- Discover our top product TIA1 Primary Antibody
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- 应用备注
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Known_Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.
Positive_Control: Human tonsil, spleen and lymph node.
- 限制
- 仅限研究用
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- 浓度
- 1.0 mg/mL
- 缓冲液
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
- 储存液
- Azide free
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
- 有效期
- 24 months
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- 抗原
- TIA1 (TIA1 Cytotoxic Granule-Associated RNA Binding Protein (TIA1))
- 别名
- TIA1 (TIA1 产品)
- 别名
- tia1 antibody, 2310050N03Rik antibody, AI256674 antibody, TIA-1 antibody, mTIA-1 antibody, WDM antibody, TIAL1 antibody, TIAR antibody, tia-1 antibody, nucleolysin TIA-1 isoform p40 antibody, hypothetical protein antibody, nucleolysin TIAR antibody, nucleolysin tia-1 antibody, nucleolysin TIA-1 antibody, cytotoxic granule-associated RNA binding protein 1 antibody, TIA1 cytotoxic granule associated RNA binding protein antibody, TIA1 cytotoxic granule-associated RNA binding protein antibody, TIA1 cytotoxic granule-associated RNA binding protein L homeolog antibody, PTRG_10065 antibody, PGTG_08590 antibody, LOC5568274 antibody, CpipJ_CPIJ013665 antibody, VDBG_07004 antibody, MGYG_03339 antibody, Tsp_15456 antibody, tia1 antibody, Tia1 antibody, TIA1 antibody, tia1.L antibody
- 背景
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Cytotoxic granule associated RNA binding protein 1, mTIA-1, Nucleolysin TIA1 isoform p40, p40-TIA-1, RNA binding protein TIA1, TIAL1, TIAR, WDM,TIA1 (T-Cell-Restricted Intracellular Antigen-1)
Cellular localisation: Cytoplasmic granule. Nucleus. Accumulates in cytoplasmic stress granules (SG) following cellular damage. - 分子量
- 40kDa
- 基因ID
- 7072, 413123
- UniProt
- P31483
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