PRMT6 抗体
Quick Overview for PRMT6 抗体 (ABIN7126821)
抗原
See all PRMT6 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
- A class of proteins termed type 1 protein arginine N-methyltransferase (PRMT) enzymes contribute to posttranslational modification of RNA-binding proteins, but differ in substrate specificities, oligomerization properties and subcellular localization. PRMTs contain an S-adenosylmethione motif which functions to add one or two methyl groups to guanidino nitrogens of arginine (R) side chains. PRMT6, also known as HRMT1L6, is a nuclear protein belonging to the PRMT family and is predominantly expressed in testis and kidney. It is known to methylate Histones H3, H4 and H2A. PRMT6 is the major dimethyltransferase for Histone H3 and specifically methylates Histone H3 at R2. Methylation at Histone H3 R2 acts to inhibit Histone H3 K4 trimethylation and ultimately leads to the transcriptional repression of genes that are activated by Histone H3 K4 trimethylation. In addition, PRMT6 methylates HIV TAT, possibly functioning as a form of cellular innate immunity to restrict levels of HIV replication.
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交叉反应 （详细）
- Human. Predicted to react with Rat.
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纯化方法
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
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免疫原
- Recombinant full-length human PRMT6 protein
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亚型
- IgG2b
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anti-Protein Arginine Methyltransferase 6 (PRMT6) (AA 1-316) antibody
PRMT6 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 3C3 unconjugated
anti-Protein Arginine Methyltransferase 6 (PRMT6) (AA 19-48) antibodyPRMT6 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Protein Arginine Methyltransferase 6 (PRMT6) (AA 119-375) antibodyPRMT6 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Protein Arginine Methyltransferase 6 (PRMT6) (AA 1-316) antibodyPRMT6 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Protein Arginine Methyltransferase 6 (PRMT6) (AA 1-316) antibodyPRMT6 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Protein Arginine Methyltransferase 6 (PRMT6) antibodyPRMT6 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Protein Arginine Methyltransferase 6 (PRMT6) (AA 301-375) antibodyPRMT6 适用: 人, 小鼠, 大鼠 ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Protein Arginine Methyltransferase 6 (PRMT6) (Internal Region) antibodyVerified PRMT6 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Protein Arginine Methyltransferase 6 (PRMT6) (C-Term) antibodyPRMT6 适用: 人, 大鼠, 犬, 马, Cow, 豚鼠, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Protein Arginine Methyltransferase 6 (PRMT6) (N-Term) antibodyPRMT6 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
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Known_Application: Immunoprecipitation (1-2 μg per 100-500 μg of total protein (1 mL of cell lysate)), ,Flow Cytometry (1-2 μg/million cells), Immunofluorescence (1-2 μg/mL), ,Optimal dilution for a specific application should be determined.
Positive_Control: HeLa, MCF7 or HepG2 cells.
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限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
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储存液
- Azide free
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储存条件
- -20 °C,-80 °C
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储存方法
- Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
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有效期
- 24 months
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- PRMT6 (Protein Arginine Methyltransferase 6 (PRMT6))
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别名
- PRMT6
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背景
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Chromobox protein homolog 7, Heterogeneous nuclear ribonucleoprotein methyltransferase like protein 6, Histone-arginine N-methyltransferase PRMT6, HMT1 hnRNP methyltransferase like 6., HRMT1L6,PRMT6
Cellular localisation: Nucleus. -
分子量
- 42kDa
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基因ID
- 55170, 26006
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UniProt
- Q96LA8
抗原
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