PMS1 抗体
Quick Overview for PMS1 抗体 (ABIN7126799)
抗原
See all PMS1 抗体适用
宿主
克隆类型
标记
应用范围
-
-
特异性
- The finding that mutations in DNA mismatch repair genes are associated with hereditary nonpolyposis colorectal cancer (HNPCC) has resulted in considerable interest in the understanding of the mechanism of DNA mismatch repair. Initially, inherited mutations in the MSH2 and MLH1 homologs of the bacterial DNA mismatch repair genes MutS and MutL were demonstrated at high frequency in HNPCC and were shown to be associated with microsatellite instability. The demonstration that 10 to 45 % of pancreatic, gastric, breast, ovarian and small cell lung cancers also display microsatellite instability has been interpreted to suggest that DNA mismatch repair is not restricted to HNPCC tumors but is a common feature in tumor initiation or progression. Two additional homologs of the prokaryotic MutL gene, designated PMS1 and PMS2, have been identified and shown to be mutated in the germline of HNPCC patients.
-
交叉反应 （详细）
- Human.
-
纯化方法
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
-
免疫原
- Recombinant full-length human PMS1 protein
-
亚型
- IgG1
-
-
anti-PMS1 Postmeiotic Segregation Increased 1 (S. Cerevisiae) (PMS1) (AA 26-135) antibody
PMS1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2G10 unconjugated
anti-PMS1 Postmeiotic Segregation Increased 1 (S. Cerevisiae) (PMS1) (Internal Region) antibodyPMS1 适用: 人, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-PMS1 Postmeiotic Segregation Increased 1 (S. Cerevisiae) (PMS1) (AA 405-619) antibodyPMS1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-PMS1 Postmeiotic Segregation Increased 1 (S. Cerevisiae) (PMS1) (AA 21-120) antibodyPMS1 适用: 人 ELISA, IF (cc), IF (p), IHC (p), IHC (fro), ICC 宿主: 兔 Polyclonal unconjugated
anti-PMS1 Postmeiotic Segregation Increased 1 (S. Cerevisiae) (PMS1) antibodyPMS1 适用: 人, 大鼠, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-PMS1 Postmeiotic Segregation Increased 1 (S. Cerevisiae) (PMS1) (AA 26-135) antibodyPMS1 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-PMS1 Postmeiotic Segregation Increased 1 (S. Cerevisiae) (PMS1) (Center) antibodyPMS1 适用: 人, 大鼠, 小鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
-
Known_Application: ELISA (concentration is assay dependent), ,Immunoprecipitation (1-2 μg per 100-500 μg of total protein (1 mL of cell lysate)), ,Flow Cytometry (1-2 μg/million cells), Immunofluorescence (1-2 μg/mL), ,Optimal dilution for a specific application should be determined.
Positive_Control: HeLa, U-251 MG or CACO-2 cells.
-
限制
- 仅限研究用
-
-
-
浓度
- 1.0 mg/mL
-
缓冲液
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
-
储存液
- Azide free
-
储存条件
- -20 °C,-80 °C
-
储存方法
- Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
-
有效期
- 24 months
-
-
- PMS1 (PMS1 Postmeiotic Segregation Increased 1 (S. Cerevisiae) (PMS1))
-
别名
- PMS1
-
背景
-
DNA mismatch repair protein PMS1, HNPCC3, hPMS1, Human homolog of yeast mutL, PMS1 postmeiotic segregation increased 1 (S. cerevisiae), PMS1 protein homolog 1, PMSL1, Rhabdomyosarcoma antigen MU RMS 40.10B / 40.10E,PMS1
Cellular localisation: Nucleus. Nuclear bodies. -
分子量
- 105.8kDa
-
基因ID
- 5378, 111749
-
UniProt
- P54277
抗原
-
