MERTK 抗体 (AA 55-148)
Quick Overview for MERTK 抗体 (AA 55-148) (ABIN7126187)
抗原
See all MERTK 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 55-148
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特异性
- MerTK, also called c-Mer, is a member of the Mer/Axl/Tyro3 receptor kinase family. It is a 984 residue transmembrane protein made up of one tyrosine kinase domain, two Fibronectin type-III domains and two immunoglobulinlike C2-type domains. MerTK is the mammalian ortholog of the chicken retroviral oncogene product v-Eyk. This protein plays a critical role in macrophage activation, platelet aggregation, clot stability and the efficient removal of apoptotic cells. Specifically, MerTK acts as a signaling molecule, triggering outer segment ingestion in the retinal pigment epithelium (RPE) phagocytic process. Evidence suggests that MerTK signals via interaction with phosphatidylinositol-specific phospholipase C i³2 (PI-PLC i³2). When the gene encoding for MerTK is mutated, the RPE phagocytosis pathway is disrupted and autosomal recessive retinitis pigmentosa (RP) may result, leading to degeneration of retinal photoreceptor cells.
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交叉反应 （详细）
- Human. Others not known.
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纯化方法
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
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免疫原
- Recombinant human MERTK protein fragment (around aa 55-148) (exact sequence is proprietary)
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亚型
- IgG2a
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anti-C-Mer Proto-Oncogene Tyrosine Kinase (MERTK) (AA 587-858) antibody
MERTK 适用: 人 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-C-Mer Proto-Oncogene Tyrosine Kinase (MERTK) (AA 501-600) antibodyMERTK 适用: 小鼠 ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-C-Mer Proto-Oncogene Tyrosine Kinase (MERTK) antibodyMERTK 适用: 人 WB, IHC, ELISA, IF, FACS 宿主: 兔 Polyclonal unconjugated
anti-C-Mer Proto-Oncogene Tyrosine Kinase (MERTK) (AA 55-148) antibodyMERTK 适用: 人 IHC, IHC (f) 宿主: 小鼠 Monoclonal MERTK-3015 unconjugated
anti-C-Mer Proto-Oncogene Tyrosine Kinase (MERTK) (AA 402-416), (Extracellular) antibodyMERTK 适用: 小鼠 WB, IHC, IF, FACS 宿主: 兔 Polyclonal unconjugated
anti-C-Mer Proto-Oncogene Tyrosine Kinase (MERTK) (AA 840-999) antibodyMERTK 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-C-Mer Proto-Oncogene Tyrosine Kinase (MERTK) (AA 21-120) antibodyMERTK 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2D2 unconjugated
anti-C-Mer Proto-Oncogene Tyrosine Kinase (MERTK) antibodyMERTK 适用: 人 WB, IF, FACS, IHC (p) 宿主: 兔 Polyclonal RB17701 unconjugated
anti-C-Mer Proto-Oncogene Tyrosine Kinase (MERTK) (AA 946-980), (C-Term) antibodyMERTK 适用: 小鼠, 大鼠 WB 宿主: 兔 Polyclonal RB50416 unconjugated
anti-C-Mer Proto-Oncogene Tyrosine Kinase (MERTK) (Extracellular Domain) antibodyMERTK 适用: 人 WB 宿主: 小鼠 Monoclonal A311F9G3 unconjugated
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应用备注
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Known_Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.
Positive_Control: Human colon tissue (IHC).
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限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
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储存液
- Azide free
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储存条件
- -20 °C,-80 °C
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储存方法
- Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
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有效期
- 24 months
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- MERTK (C-Mer Proto-Oncogene Tyrosine Kinase (MERTK))
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别名
- MERTK
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背景
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CEyk, MER receptor tyrosine kinase, MERK, MERPEN, nmf12, Nyk, Proto-oncogene c-Mer, RP38, STK kinase,MerTK (Innate Immune Checkpoint)
Cellular localisation: Cell surface. -
分子量
- 110kDa
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基因ID
- 10461, 306178
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UniProt
- Q12866
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途径
- RTK signaling
抗原
-
