MICA 抗体 (AA 1-200)
Quick Overview for MICA 抗体 (AA 1-200) (ABIN7504179)
抗原
See all MICA 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-200
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特异性
- MICA and MICB are stress-induced antigens that are related to major histocompatibility complex (MHC) class I molecules. MICA and MICB are frequently expressed in epithelial tumors. These highly glycosylated cell surface proteins are stably expressed without conventional class I peptide ligands or association with i²-2-microglobulin. The expression is induced on proliferating or heat shock-stressed epithelial cells. MICA and MICB are broadly recognized by intestinal epithelial V L1 i³ L T cells expressing variable TCRs, suggesting that these antigens may play a central role in the signaling of cellular distress to evoke immune responses in the intestinal epithelium.
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交叉反应 （详细）
- Human, Mouse and Rat.
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纯化方法
- 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.
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免疫原
- Recombinant fragment (around aa1-200) of human MICA (exact sequence is proprietary)
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亚型
- IgG2b
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anti-MHC Class I Polypeptide-Related Sequence A (MICA) (AA 68-97) antibody
MICA 适用: 人 WB, FACS, IF, IHC (p) 宿主: 兔 Polyclonal RB21777 unconjugated
anti-MHC Class I Polypeptide-Related Sequence A (MICA) (AA 120-170) antibodyMICA 适用: 人 WB, IHC (p), IF (p) 宿主: 兔 Polyclonal unconjugated
anti-MHC Class I Polypeptide-Related Sequence A (MICA) antibodyMICA 适用: 人 WB, FACS, IP 宿主: 小鼠 Monoclonal MEM-147 unconjugated
anti-MHC Class I Polypeptide-Related Sequence A (MICA) antibodyMICA 适用: 人, Cow, Cat, Non-Human Primate ELISA, FACS, IP, ICC, IHC (fro), Func, MS 宿主: 小鼠 Monoclonal W6-32 unconjugated
anti-MHC Class I Polypeptide-Related Sequence A (MICA) antibodyMICA 适用: 人, Cow, Cat, Non-Human Primate ELISA, FACS, IP, ICC, IHC (fro), MS 宿主: 小鼠 Monoclonal W6-32 unconjugated
anti-MHC Class I Polypeptide-Related Sequence A (MICA) antibody (Biotin)MICA 适用: 人, Cow, Cat, Non-Human Primate ELISA, FACS, IP, ICC, IHC (fro) 宿主: 小鼠 Monoclonal W6-32 Biotin
anti-MHC Class I Polypeptide-Related Sequence A (MICA) antibody (FITC)MICA 适用: 人, Cow, Cat, Non-Human Primate FACS 宿主: 小鼠 Monoclonal W6-32 FITC
anti-MHC Class I Polypeptide-Related Sequence A (MICA) antibody (PE)MICA 适用: 人, Cow, Cat, Non-Human Primate FACS 宿主: 小鼠 Monoclonal W6-32 PE
anti-MHC Class I Polypeptide-Related Sequence A (MICA) antibody (PE)MICA 适用: 人 FACS 宿主: 小鼠 Monoclonal MEM-147 PE
anti-MHC Class I Polypeptide-Related Sequence A (MICA) (AA 24-307) antibodyMICA 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
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Positive Control: HeLa or MCF-7 cells. Human breast, kidney or prostate.
Known Application: Western Blot (1-2 μg/mL),Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.
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限制
- 仅限研究用
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浓度
- 200 μg/mL
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缓冲液
- Prepared in 10 mM PBS with 0.05 % BSA and 0.05 % azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-80 °C
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储存方法
- Antibody with azide - store at 2 to 8 °C. Antibody is stable for 24 months. Non-hazardous. Also available WITHOUT BSA & azide at 1.0mg/ml.
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有效期
- 24 months
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- MICA (MHC Class I Polypeptide-Related Sequence A (MICA))
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别名
- MICA
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背景
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HLA class I antigen, MHC class I chain related gene A protein antibody, MHC class I chain related protein A, MHC class I chain related protein A HLA B HLA C, MHC class I polypeptide related sequence A, MHC class I polypeptide-related sequence A, MHC class I related protein, MIC A, MIC-A, micA, PERB11.1, Stress inducible class I homolog,MICA
Cellular localisation: Cell surface. Cytoplasm. -
分子量
- 92kDa
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基因ID
- 100507436
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UniProt
- Q29983
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途径
- Activation of Innate immune Response, Transition Metal Ion Homeostasis, Human Leukocyte Antigen (HLA) in Adaptive Immune Response
抗原
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