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WTAP 抗体

This anti-WTAP antibody is a 小鼠 单克隆 antibody detecting WTAP in WB, ELISA 和 IHC. Suitable for 人, 小鼠 和 大鼠.
产品编号 ABIN7120845
发货至: 中国

Quick Overview for WTAP 抗体 (ABIN7120845)

抗原

See all WTAP 抗体
WTAP (Wilms Tumor 1 Associated Protein (WTAP))

适用

  • 48
  • 14
  • 4
  • 2
  • 1
  • 1
  • 1
  • 1
人, 小鼠, 大鼠

宿主

  • 42
  • 6
小鼠

克隆类型

  • 41
  • 7
单克隆

标记

  • 32
  • 3
  • 3
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
This WTAP antibody is un-conjugated

应用范围

  • 33
  • 24
  • 17
  • 8
  • 8
  • 6
  • 5
  • 3
  • 2
  • 1
  • 1
  • 1
Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

克隆位点

9D4
  • 纯化方法

    Protein A+G purification

    纯度

    ≥95 % as determined by SDS-PAGE

    免疫原

    Wilms tumor 1 associated protein

    亚型

    IgG1
  • 应用备注

    WB: 1:1000-1:10000, IHC: 1:50-1:500

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

    有效期

    12 months
  • 抗原

    WTAP (Wilms Tumor 1 Associated Protein (WTAP))

    别名

    WTAP

    背景

    Synonyms:DKFZp686F20131, Female lethal(2)D homolog, hFL(2)D, KIAA0105, WT1 associated protein, WTAP Background:Regulatory subunit of the WMM N6-methyltransferase complex, a multiprotein complex that mediates N6-methyladenosine(m6A) methylation of some adenosine residues of some mRNAs and plays a role in the efficiency of mRNA splicing, processing and mRNA stability. Required for accumulation of METTL3 and METTL14 to nuclear speckle(PubMed:24316715, PubMed:24407421, PubMed:24981863). Acts as a mRNA splicing regulator(PubMed:12444081). Regulates G2/M cell-cycle transition by binding to the 3' UTR of CCNA2, which enhances its stability(PubMed:17088532). Impairs WT1 DNA-binding ability and inhibits expression of WT1 target genes(PubMed:17095724).

    分子量

    49 kDa

    基因ID

    9589

    UniProt

    Q15007
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