WTAP 抗体 (AA 1-150)
Quick Overview for WTAP 抗体 (AA 1-150) (ABIN7120845)
抗原
See all WTAP 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 1-150
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原理
- WTAP antibody
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纯化方法
- Protein A+G purification
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
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Immunogen sequence: 1-150aa
Immunogen: Wilms tumor 1 associated protein
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亚型
- IgG1
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应用备注
- WB: 1:1000-1:10000, IHC: 1:50-1:500
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- WTAP (Wilms Tumor 1 Associated Protein (WTAP))
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别名
- WTAP
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背景
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Synonyms: Pre-mRNA-splicing regulator WTAP|Female-lethal(2)D homolog (hFL(2)D)|WT1-associated protein|Wilms tumor 1-associating protein|WTAP|KIAA0105
Background: Regulatory subunit of the WMM N6-methyltransferase complex, a multiprotein complex that mediates N6-methyladenosine(m6A) methylation of some adenosine residues of some mRNAs and plays a role in the efficiency of mRNA splicing, processing and mRNA stability. Required for accumulation of METTL3 and METTL14 to nuclear speckle(PubMed:24316715, PubMed:24407421, PubMed:24981863). Acts as a mRNA splicing regulator(PubMed:12444081). Regulates G2/M cell-cycle transition by binding to the 3' UTR of CCNA2, which enhances its stability(PubMed:17088532). Impairs WT1 DNA-binding ability and inhibits expression of WT1 target genes(PubMed:17095724).
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分子量
- 49 kDa
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基因ID
- 9589
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UniProt
- Q15007
抗原
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